PMID- 28813699
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20180813
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 138
IP  - 4
DP  - 2017
TI  - T1 and T2 Mapping in Cardiology: "Mapping the Obscure Object of Desire".
PG  - 207-217
LID - 10.1159/000478901 [doi]
AB  - The increasing use of cardiovascular magnetic resonance (CMR) is based on its 
      capability to perform biventricular function assessment and tissue 
      characterization without radiation and with high reproducibility. The use of late 
      gadolinium enhancement (LGE) gave the potential of non-invasive biopsy for 
      fibrosis quantification. However, LGE is unable to detect diffuse myocardial 
      disease. Native T1 mapping and extracellular volume fraction (ECV) provide 
      knowledge about pathologies affecting both the myocardium and interstitium that 
      is otherwise difficult to identify. Changes of myocardial native T1 reflect 
      cardiac diseases (acute coronary syndromes, infarction, myocarditis, and diffuse 
      fibrosis, all with high T1) and systemic diseases such as cardiac amyloid (high 
      T1), Anderson-Fabry disease (low T1), and siderosis (low T1). The ECV, an index 
      generated by native and post-contrast T1 mapping, measures the cellular and 
      extracellular interstitial matrix (ECM) compartments. This myocyte-ECM dichotomy 
      has important implications for identifying specific therapeutic targets of great 
      value for heart failure treatment. On the other hand, T2 mapping is superior 
      compared with myocardial T1 and ECM for assessing the activity of myocarditis in 
      recent-onset heart failure. Although these indices can significantly affect the 
      clinical decision making, multicentre studies and a community-wide approach 
      (including MRI vendors, funding, software, contrast agent manufacturers, and 
      clinicians) are still missing.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Mavrogeni, Sophie
AU  - Mavrogeni S
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Apostolou, Dimitris
AU  - Apostolou D
FAU - Argyriou, Panayiotis
AU  - Argyriou P
FAU - Velitsista, Stella
AU  - Velitsista S
FAU - Papa, Lilika
AU  - Papa L
FAU - Efentakis, Stelios
AU  - Efentakis S
FAU - Vernardos, Evangelos
AU  - Vernardos E
FAU - Kanoupaki, Mikela
AU  - Kanoupaki M
FAU - Kanoupakis, George
AU  - Kanoupakis G
FAU - Manginas, Athanassios
AU  - Manginas A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170817
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
SB  - IM
MH  - Fibrosis
MH  - Heart/diagnostic imaging/*physiopathology
MH  - Heart Diseases/*diagnostic imaging
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Myocardium/*pathology
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Heart diseases
OT  - T1 mapping
OT  - T2 mapping
EDAT- 2017/08/17 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/08/17 06:00
PHST- 2017/03/21 00:00 [received]
PHST- 2017/06/21 00:00 [accepted]
PHST- 2017/08/17 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/08/17 06:00 [entrez]
AID - 000478901 [pii]
AID - 10.1159/000478901 [doi]
PST - ppublish
SO  - Cardiology. 2017;138(4):207-217. doi: 10.1159/000478901. Epub 2017 Aug 17.