PMID- 28814087
OWN - NLM
STAT- MEDLINE
DCOM- 20171208
LR  - 20191210
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 118
IP  - 2
DP  - 2017
TI  - Effects of sevoflurane on apoptosis, BDNF and cognitive functions in neonatal 
      rats.
PG  - 80-84
LID - 10.4149/BLL_2017_017 [doi]
AB  - OBJECTIVE: To evaluate the early and late effects of sevoflurane on the neonatal 
      brain. BACKGROUND: Sevoflurane is the most used anaesthetics in neonatal 
      subjects. METHODS: The study included 7-day-old male Wistar-Albino rats (n = 30), 
      which were divided into the two groups according to the anaesthetic received: 
      sevoflurane (S) and control group (C). Half of each group was sacrificed six 
      hours after anaesthesia (early, E) while the remaining subjects were sacrificed 
      six weeks later (late, L). The serum brain-derived-neurotrophic factor (BDNF), 
      brain BDNF and caspase-3 were evaluated. In addition, elevated plus arm test and 
      Morris water test were performed in the late group. RESULTS: BDNF levels were 
      higher in the late groups than in the early ones (p < 0.05). BDNF levels in 
      cerebral cortex were higher in the Group CE than in the Group CL and SL (p < 
      0.05). There was a significant negative correlation between serum BDNF and cortex 
      BDNF levels (p = 0.003, r = -0.425). Cortex caspase 3 levels were significantly 
      higher in the Groups SE and SL than in the Group CE and CL (p < 0.05). There was 
      no significant difference between the groups in the terms of open arm index, 
      locomotor activity and Morris water test. CONCLUSIONS: Although sevoflurane 
      induced apoptosis, it didn't affect BDNF levels and showed no long-term negative 
      effects on learning and anxiety in neonatal rats (Tab. 1, Fig. 3, Ref. 26).
FAU - Ozer, A B
AU  - Ozer AB
FAU - Ceribasi, S
AU  - Ceribasi S
FAU - Ceribasi, A O
AU  - Ceribasi AO
FAU - Demirel, I
AU  - Demirel I
FAU - Bayar, M K
AU  - Bayar MK
FAU - Ustundag, B
AU  - Ustundag B
FAU - Ileri, A
AU  - Ileri A
FAU - Erhan, O L
AU  - Erhan OL
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Methyl Ethers)
RN  - 0 (brain-derived integrating factor-1, rat)
RN  - 38LVP0K73A (Sevoflurane)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Anesthetics, Inhalation/administration & dosage/*pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Apoptosis/*drug effects
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Caspase 3/blood
MH  - Cell Cycle Proteins
MH  - Cerebral Cortex/metabolism
MH  - Cognition/*drug effects
MH  - Cognition Disorders
MH  - Intracellular Signaling Peptides and Proteins/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Methyl Ethers/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sevoflurane
OTO - NOTNLM
OT  - anesthesia
OT  - apoptosis BDNF.
OT  - neonatal
EDAT- 2017/08/18 06:00
MHDA- 2017/12/09 06:00
CRDT- 2017/08/18 06:00
PHST- 2017/08/18 06:00 [entrez]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2017/12/09 06:00 [medline]
AID - 10.4149/BLL_2017_017 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2017;118(2):80-84. doi: 10.4149/BLL_2017_017.