PMID- 28814127
OWN - NLM
STAT- MEDLINE
DCOM- 20180914
LR  - 20180914
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 12
IP  - 18
DP  - 2017 Sep
TI  - Carbon nanotubes functionalized with folic acid attached via biomimetic peptide 
      linker.
PG  - 2161-2182
LID - 10.2217/nnm-2017-0120 [doi]
AB  - AIM: Anchoring folic acid (FA) with a biomimetic peptidic linker resistant to 
      proteolytic degradation to act as a homing device on functionalized carbon 
      nanotubes. MATERIALS & METHODS: Ethylenediamine was attached to oxidized 
      multiwalled carbon nanotubes (MWNTs) using 
      4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylmorpholinium tetrafluoroborate. FA 
      was coupled with 6-aminohexanoic acid and derivatives of beta-alanine, affording 
      four intermediates, which connected to the MWNTs via peptidic linkers of various 
      lengths. RESULTS: Biomimetic nanomaterials were produced with FA as a homing 
      molecule. The structure and properties of the nanomaterials were analyzed, 
      confirming the versatility of the peptides used as linkers. CONCLUSION: 
      Conjugates of FA attached to MWNTs via peptide linkers prepared from beta-alanine 
      residues are resistant to proteolytic degradation. Viability in colon cancer 
      cells and normal colonocytes confirmed their lack of cytotoxicity.
FAU - Fraczyk, Justyna
AU  - Fraczyk J
AD  - Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of 
      Technology, Zeromskiego 116, 90924 Lodz, Poland.
FAU - Walczak, Malgorzata
AU  - Walczak M
AD  - Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of 
      Technology, Zeromskiego 116, 90924 Lodz, Poland.
FAU - Szymanski, Lukasz
AU  - Szymanski L
AD  - Institute of Mechatronics & Information Systems, Lodz University of Technology, 
      Stefanowskiego 18/22, 90924 Lodz, Poland.
FAU - Kolacinski, Zbigniew
AU  - Kolacinski Z
AD  - Institute of Mechatronics & Information Systems, Lodz University of Technology, 
      Stefanowskiego 18/22, 90924 Lodz, Poland.
FAU - Wrzosek, Henryk
AU  - Wrzosek H
AD  - Department of Material & Commodity Sciences & Textile Metrology, Lodz University 
      of Technology, Zeromskiego 116, 90924 Lodz, Poland.
FAU - Majsterek, Ireneusz
AU  - Majsterek I
AD  - Department of Clinical Chemistry & Biochemistry, Medical University of Lodz, Plac 
      Hallera 1, 90647 Lodz, Poland.
FAU - Przybylowska-Sygut, Karolina
AU  - Przybylowska-Sygut K
AD  - Department of Clinical Chemistry & Biochemistry, Medical University of Lodz, Plac 
      Hallera 1, 90647 Lodz, Poland.
FAU - Kaminski, Zbigniew J
AU  - Kaminski ZJ
AD  - Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of 
      Technology, Zeromskiego 116, 90924 Lodz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Borates)
RN  - 0 (Ethylenediamines)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Oligopeptides)
RN  - 11P2JDE17B (beta-Alanine)
RN  - 60V9STC53F (ethylenediamine)
RN  - 935E97BOY8 (Folic Acid)
RN  - H429WZ9FBQ (fluoroboric acid)
RN  - U6F3787206 (Aminocaproic Acid)
SB  - IM
MH  - Aminocaproic Acid/chemistry
MH  - Biomimetic Materials/*chemistry
MH  - Borates/chemistry
MH  - Cell Line
MH  - Cell Survival
MH  - Drug Delivery Systems
MH  - Ethylenediamines/chemistry
MH  - Folic Acid/*chemistry
MH  - HT29 Cells
MH  - Humans
MH  - Hydrolysis
MH  - Nanotubes, Carbon/*chemistry/toxicity
MH  - Oligopeptides/*chemistry
MH  - Particle Size
MH  - Surface Properties
MH  - beta-Alanine/*analogs & derivatives/*chemistry
OTO - NOTNLM
OT  - biomimetics
OT  - carbon nanotubes
OT  - folate derivative
OT  - peptide linker
OT  - triazine-based coupling reagent
EDAT- 2017/08/18 06:00
MHDA- 2018/09/15 06:00
CRDT- 2017/08/18 06:00
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2018/09/15 06:00 [medline]
PHST- 2017/08/18 06:00 [entrez]
AID - 10.2217/nnm-2017-0120 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2017 Sep;12(18):2161-2182. doi: 10.2217/nnm-2017-0120. Epub 
      2017 Aug 17.