PMID- 28814355
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20181202
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 38
IP  - 5
DP  - 2017 Sep 1
TI  - Der p 1 and Der p 2 specific immunoglobulin E measurement for diagnosis of 
      Dermatophagoides pteronyssinus allergy: A systematic review and meta-analysis.
PG  - 333-342
LID - 10.2500/aap.2017.38.4073 [doi]
AB  - BACKGROUND: A clinical history of allergic symptoms and a skin-prick test with 
      house-dust mite crude extracts are standard diagnostic procedures for 
      Dermatophagoides pteronyssinus allergy. Specific immunoglobulin E (IgE) responses 
      to Der p 1 and Der p 2 allergens have been used for the diagnosis of D. 
      pteronyssinus allergy; however, evaluation of the diagnostic performance of Der p 
      1 and Der p 2 specific IgE (sIgE) produced inconsistent findings. We sought to 
      evaluate the diagnostic accuracy of Der p 1 sIgE and Der p 2 sIgE measurement in 
      the diagnosis of D. pteronyssinus allergy by performing a systematic review and 
      meta-analysis of previously published studies. METHODS: Several medical 
      literature electronic data bases were searched for related literature published 
      through August 1, 2016. A bivariate model was used to pool estimates of 
      sensitivity, specificity, diagnostic odds ratio, and area under the summary 
      receiver operating curves as the main diagnostic measures. RESULTS: Eight 
      studies, which involved 1095 patients, were included in our analysis. The pooled 
      estimates of sensitivity, specificity, and diagnostic odds ratio for Der p 1 were 
      0.84, 0.97, and 166.57, respectively. The combined results for Der p 2 were a 
      sensitivity of 0.87, specificity of 1.00, and a diagnostic odds ratio of 
      17342.35. The areas under the summary receiver operating curves for Der p 1 sIgE 
      and Der p 2 sIgE were 0.94 and 0.98, respectively. CONCLUSION: Our results 
      supported the use of Der p 1 and Der p 2 sIgE in the diagnosis of D. 
      pteronyssinus allergy. Both displayed good diagnostic performance and would be 
      useful in a clinical setting in the accurate diagnosis of dust mite allergy.
FAU - Tian, Man
AU  - Tian M
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Zhang, Wenxin
AU  - Zhang W
FAU - Cui, Yubao
AU  - Cui Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (Dermatophagoides pteronyssinus antigen p 2)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.- (Dermatophagoides pteronyssinus antigen p 1)
SB  - IM
CIN - Allergy Asthma Proc. 2017 Sep 1;38(5):331-332. PMID: 28814354
MH  - Allergens/*immunology
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Antigens, Dermatophagoides/*immunology
MH  - Arthropod Proteins/*immunology
MH  - Cysteine Endopeptidases/*immunology
MH  - Dermatophagoides pteronyssinus/*immunology
MH  - Humans
MH  - Hypersensitivity/*diagnosis/*immunology
MH  - Immunoglobulin E/blood/*immunology
MH  - Odds Ratio
MH  - Publication Bias
MH  - ROC Curve
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Skin Tests
EDAT- 2017/08/18 06:00
MHDA- 2018/04/24 06:00
CRDT- 2017/08/18 06:00
PHST- 2017/08/18 06:00 [entrez]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
AID - 10.2500/aap.2017.38.4073 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2017 Sep 1;38(5):333-342. doi: 10.2500/aap.2017.38.4073.