PMID- 28816008
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20220408
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 22
IP  - 1
DP  - 2018 Jan
TI  - Lactuca capensis reverses memory deficits in Abeta1-42-induced an animal model of 
      Alzheimer's disease.
PG  - 111-122
LID - 10.1111/jcmm.13299 [doi]
AB  - We investigated the neuropharmacological effects of the methanolic extract from 
      Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory 
      impairment in an Alzheimer's disease (AD) rat model produced by direct 
      intraventricular delivery of amyloid-beta1-42 (Abeta1-42). Behavioural assays such as 
      Y-maze and radial arm maze test were used for assessing memory performance. 
      Abeta1-42 decreased cognitive performance in the behavioural tests which were 
      ameliorated by pre-treatment with the methanolic extract. Acetylcholinesterase 
      activity and oxidant-antioxidant balance in the rat hippocampus were abnormally 
      altered by Abeta1-42 treatment while these deficits were recovered by pre-treatment 
      with the methanolic extract. In addition, rats were given Abeta1-42 exhibited in the 
      hippocampus decreased brain-derived neurotrophic factor (BDNF) mRNA copy number 
      and increased IL-1beta mRNA copy number which was reversed by the methanolic extract 
      administration. These findings suggest that the methanolic extract could be a 
      potent neuropharmacological agent against dementia via modulating cholinergic 
      activity, increasing of BDNF levels and promoting antioxidant action in the rat 
      hippocampus.
CI  - (c) 2017 The Authors. Journal of Cellular and Molecular Medicine published by John 
      Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
FAU - Postu, Paula Alexandra
AU  - Postu PA
AD  - Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
FAU - Noumedem, Jaures A K
AU  - Noumedem JAK
AUID- ORCID: 0000-0002-5455-2391
AD  - Pole Recherche Innovation et Entrepreneuriat (PRIE), Institut Universitaire de la 
      Cote, Douala, Cameroon.
FAU - Cioanca, Oana
AU  - Cioanca O
AD  - Faculty of Pharmacy, University of Medicine and Pharmacy 'Gr. T. Popa', Iasi, 
      Romania.
FAU - Hancianu, Monica
AU  - Hancianu M
AD  - Faculty of Pharmacy, University of Medicine and Pharmacy 'Gr. T. Popa', Iasi, 
      Romania.
FAU - Mihasan, Marius
AU  - Mihasan M
AD  - Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
FAU - Ciorpac, Mitica
AU  - Ciorpac M
AD  - Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
FAU - Gorgan, Dragos Lucian
AU  - Gorgan DL
AD  - Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
FAU - Petre, Brindusa Alina
AU  - Petre BA
AD  - Department of Chemistry, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
FAU - Hritcu, Lucian
AU  - Hritcu L
AD  - Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170816
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Peptide Fragments)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - Alzheimer Disease/*drug therapy/physiopathology
MH  - Amyloid beta-Peptides
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Asteraceae/*chemistry
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cholinesterase Inhibitors/pharmacology/therapeutic use
MH  - DNA Fragmentation/drug effects
MH  - Disease Models, Animal
MH  - Gene Dosage
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Interleukin-1beta/genetics/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy/physiopathology
MH  - Methanol
MH  - Peptide Fragments
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Plant Leaves/chemistry
MH  - Protein Carbonylation/drug effects
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats, Wistar
MH  - Spatial Memory/drug effects
MH  - Superoxide Dismutase/metabolism
PMC - PMC5742732
OTO - NOTNLM
OT  - IL-1beta
OT  - Lactuca capensis extract
OT  - amyloid
OT  - antioxidant
OT  - brain-derived neurotrophic factor
OT  - dementia
EDAT- 2017/08/18 06:00
MHDA- 2019/02/05 06:00
PMCR- 2018/01/01
CRDT- 2017/08/18 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/06/03 00:00 [accepted]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2017/08/18 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - JCMM13299 [pii]
AID - 10.1111/jcmm.13299 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2018 Jan;22(1):111-122. doi: 10.1111/jcmm.13299. Epub 2017 Aug 
      16.