PMID- 28816340
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20201209
IS  - 2567-689X (Electronic)
IS  - 0340-6245 (Linking)
VI  - 117
IP  - 10
DP  - 2017 Oct 5
TI  - Coagulation factor XII regulates inflammatory responses in human lungs.
PG  - 1896-1907
LID - 10.1160/TH16-12-0904 [doi]
AB  - Increased procoagulant activity in the alveolar compartment and uncontrolled 
      inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). 
      Here, we investigated whether the contact phase system of coagulation is 
      activated and may regulate inflammatory responses in human lungs. Components of 
      the contact phase system were characterized in bronchoalveolar lavage fluids 
      (BALF) from 54 ARDS patients and 43 controls, and their impact on 
      cytokine/chemokine expression in human precision cut lung slices (PCLS) was 
      assessed by a PCR array. Activation of the contact system, associated with high 
      levels of coagulation factor XIIa (Hageman factor, FXIIa), plasma kallikrein and 
      bradykinin, occurred rapidly in ARDS lungs after the onset of the disease and 
      virtually normalized within one week from time of diagnosis. FXII levels in BALF 
      were higher in ARDS non-survivors than survivors and were positively correlated 
      with tumor necrosis factor (TNF)-alpha concentration. FXII induced the production and 
      release of interleukin (IL)-8, IL-1beta, IL-6, leukemia inhibitory factor (LIF), 
      CXCL5 and TNF-alpha in human PCLS in a kallikrein-kinin-independent manner. In 
      conclusion, accumulation of FXII in ARDS lungs may contribute to the release of 
      pro-inflammatory mediators and is associated with clinical outcome. FXII 
      inhibition may thus offer a novel and promising therapeutic approach to 
      antagonize overwhelming inflammatory responses in ARDS lungs without interfering 
      with vital haemostasis.
FAU - Hess, Rosanna
AU  - Hess R
FAU - Wujak, Lukasz
AU  - Wujak L
FAU - Hesse, Christina
AU  - Hesse C
FAU - Sewald, Katherina
AU  - Sewald K
FAU - Jonigk, Danny
AU  - Jonigk D
FAU - Warnecke, Gregor
AU  - Warnecke G
FAU - Fieguth, Hans-Gerd
AU  - Fieguth HG
FAU - de Maat, Steven
AU  - de Maat S
FAU - Maas, Coen
AU  - Maas C
FAU - Bonella, Francesco
AU  - Bonella F
FAU - Preissner, Klaus T
AU  - Preissner KT
FAU - Weiss, Benjamin
AU  - Weiss B
FAU - Schaefer, Liliana
AU  - Schaefer L
FAU - Kuebler, Wolfgang M
AU  - Kuebler WM
FAU - Markart, Philipp
AU  - Markart P
FAU - Wygrecka, Malgorzata
AU  - Wygrecka M
AD  - Malgorzata Wygrecka, PhD, Department of Biochemistry, Faculty of Medicine,, 
      Universities of Giessen and Marburg Lung Center, Friedrichstrasse 24, 35392 
      Giessen, Germany, Tel.: +49 641 99 47482, Fax: +49 641 99 47509, E-mail: 
      malgorzata.wygrecka@innere.med.uni-giessen.de.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 9001-30-3 (Factor XII)
SB  - IM
MH  - Adult
MH  - *Blood Coagulation
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Cytokines/genetics/*metabolism
MH  - Factor XII/*metabolism
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Lung/immunology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Pneumonia/blood/genetics/immunology/*metabolism
MH  - Respiratory Distress Syndrome/blood/genetics/immunology/*metabolism
MH  - Retrospective Studies
MH  - Signal Transduction
MH  - Young Adult
OTO - NOTNLM
OT  - Acute respiratory distress syndrome
OT  - coagulation factor XII
OT  - contact phase system
EDAT- 2017/08/18 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/08/18 06:00
PHST- 2016/12/01 00:00 [received]
PHST- 2017/06/23 00:00 [accepted]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/08/18 06:00 [entrez]
AID - 16-12-0904 [pii]
AID - 10.1160/TH16-12-0904 [doi]
PST - ppublish
SO  - Thromb Haemost. 2017 Oct 5;117(10):1896-1907. doi: 10.1160/TH16-12-0904. Epub 
      2017 Aug 17.