PMID- 2881638
OWN - NLM
STAT- MEDLINE
DCOM- 19870521
LR  - 20190820
IS  - 0090-1229 (Print)
IS  - 0090-1229 (Linking)
VI  - 43
IP  - 1
DP  - 1987 Apr
TI  - HTLV-I antibody and cell-mediated immunity status in sickle cell anemia.
PG  - 140-4
AB  - Patients with sickle cell anemia (SCA) had an abnormal susceptibility to 
      infections. In Martinique (French West Indies), a human T-cell leukemia/lymphoma 
      virus type I (HTLV-I) endemic area, we found that 17 (10%) of 173 SCA patients 
      had antibodies to HTLV-I. The possible relationship between HTLV-I seropositivity 
      and altered immunity was studied in 13 SCA patients with HTLV-I antibodies 
      compared with 13 matched SCA patients without HTLV-I antibodies. The 
      immunological results, as evaluated by the T-cell subsets analysis, the 
      lymphocyte proliferation responses analyzed after activation with concanavalin A, 
      phytohemagglutinin, or pokeweed mitogen, and the natural killer activity were not 
      statistically different in these two groups of patients (SCA HTLV-I positive vs 
      SCA HTLV-I negative). These data suggest that HTLV-I infection did not result in 
      a major alteration of cellular immunity in this population.
FAU - Sanhadji, K
AU  - Sanhadji K
FAU - Gessain, A
AU  - Gessain A
FAU - Chout, R
AU  - Chout R
FAU - Sasco, A J
AU  - Sasco AJ
FAU - Yoyo, M
AU  - Yoyo M
FAU - Touraine, J L
AU  - Touraine JL
FAU - de The, G
AU  - de The G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Immunol Immunopathol
JT  - Clinical immunology and immunopathology
JID - 0356637
RN  - 0 (Antibodies, Viral)
RN  - 0 (Deltaretrovirus Antibodies)
SB  - IM
MH  - Anemia, Sickle Cell/*immunology
MH  - Antibodies, Viral/analysis
MH  - Deltaretrovirus Antibodies
MH  - Humans
MH  - Immunity, Cellular
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation
MH  - Lymphocytes/classification
MH  - T-Lymphocytes, Regulatory/immunology
MH  - West Indies
EDAT- 1987/04/01 00:00
MHDA- 1987/04/01 00:01
CRDT- 1987/04/01 00:00
PHST- 1987/04/01 00:00 [pubmed]
PHST- 1987/04/01 00:01 [medline]
PHST- 1987/04/01 00:00 [entrez]
AID - 10.1016/0090-1229(87)90165-6 [doi]
PST - ppublish
SO  - Clin Immunol Immunopathol. 1987 Apr;43(1):140-4. doi: 
      10.1016/0090-1229(87)90165-6.