PMID- 28816832 OWN - NLM STAT- MEDLINE DCOM- 20180521 LR - 20220318 IS - 1537-162X (Electronic) IS - 0362-5664 (Linking) VI - 40 IP - 5 DP - 2017 Sep/Oct TI - Reversible Splenial Lesion Syndrome After Intravenous Immunoglobulin Treatment for Guillain-Barre Syndrome. PG - 224-225 LID - 10.1097/WNF.0000000000000236 [doi] AB - Reversible corpus callosum splenial (CCS) lesions have been described in patients with varied etiologies. The most common causes of previously reported reversible focal lesions of the CCS are viral encephalitis, antiepileptic drug toxicity/withdrawal, and metabolic disorders. Intravenous immunoglobulin (IVIG) therapy is used for different immune-mediated diseases. It is generally safe, and serious adverse reactions are uncommon. We presented a rare case of disturbed consciousness with reversible CCS lesions after IVIG therapy for Guillain-Barre syndrome in an adult woman. In this case, we believe that IVIG therapy caused reversible CCS lesions with encephalopathy and probably result of cytotoxic edema and/or cerebral arterial vasospasm. FAU - Uygur Kucukseymen, Elif AU - Uygur Kucukseymen E AD - Department of Neurology, Antalya Education and Research Hospital, Antalya, Turkey. FAU - Yuksel, Burcu AU - Yuksel B FAU - Genc, Fatma AU - Genc F FAU - Ozaydin Goksu, Eylem AU - Ozaydin Goksu E FAU - Yildiz, Sevim AU - Yildiz S FAU - Bicer Gomceli, Yasemin AU - Bicer Gomceli Y LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Clin Neuropharmacol JT - Clinical neuropharmacology JID - 7607910 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Corpus Callosum/diagnostic imaging/*pathology MH - Female MH - Guillain-Barre Syndrome/*drug therapy MH - Humans MH - Immunoglobulins, Intravenous/*adverse effects MH - Middle Aged MH - Syndrome EDAT- 2017/08/18 06:00 MHDA- 2018/05/22 06:00 CRDT- 2017/08/18 06:00 PHST- 2017/08/18 06:00 [pubmed] PHST- 2018/05/22 06:00 [medline] PHST- 2017/08/18 06:00 [entrez] AID - 10.1097/WNF.0000000000000236 [doi] PST - ppublish SO - Clin Neuropharmacol. 2017 Sep/Oct;40(5):224-225. doi: 10.1097/WNF.0000000000000236.