PMID- 28817076
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20181207
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 22
IP  - 8
DP  - 2017 Aug 17
TI  - Spirulina maxima Extract Prevents Neurotoxicity via Promoting Activation of 
      BDNF/CREB Signaling Pathways in Neuronal Cells and Mice.
LID - 10.3390/molecules22081363 [doi]
LID - 1363
AB  - Spirulina maxima is a microalgae which contains flavonoids and other polyphenols. 
      Although Spirulina maxima 70% ethanol extract (SM70EE) has diverse beneficial 
      effects, its effects on neurotoxicity have not been fully understood. In this 
      study, we investigated the neuroprotective effects of SM70EE against trimethyltin 
      (TMT)-induced neurotoxicity in HT-22 cells. SM70EE inhibited the cleavage of 
      poly-ADP ribose polymerase (PARP). Besides, ROS production was decreased by 
      down-regulating oxidative stress-associated enzymes. SM70EE increased the factors 
      of brain-derived neurotrophic factor (BDNF)/cyclic AMPresponsive elementbinding 
      protein (CREB) signalling pathways. Additionally, acetylcholinesterase (AChE) was 
      suppressed by SM70EE. Furthermore, we investigated whether SM70EE prevents 
      cognitive deficits against scopolamine-induced neurotoxicity in mice by applying 
      behavioral tests. SM70EE increased step-through latency time and decreased the 
      escape latency time. Therefore, our data suggest that SM70EE may prevent TMT 
      neurotoxicity through promoting activation of BDNF/CREB neuroprotective signaling 
      pathways in neuronal cells. In vivo study, SM70EE would prevent cognitive 
      deficits against scopolamine-induced neurotoxicity in mice.
FAU - Koh, Eun-Jeong
AU  - Koh EJ
AD  - Department of Food Science and Biotechnology, College of Life Science, CHA 
      University, Seongnam, Kyonggi 13488, Korea. kej763@naver.com.
FAU - Seo, Young-Jin
AU  - Seo YJ
AD  - Department of Food Science and Biotechnology, College of Life Science, CHA 
      University, Seongnam, Kyonggi 13488, Korea. yj2477@hanmail.net.
FAU - Choi, Jia
AU  - Choi J
AD  - Department of Food Science and Biotechnology, College of Life Science, CHA 
      University, Seongnam, Kyonggi 13488, Korea. wldk3176@gmail.com.
FAU - Lee, Hyeon Yong
AU  - Lee HY
AD  - Department of Food Science and Engineering, Seowon University, Cheongju 28674, 
      Korea. hyeonl@kangwon.ac.kr.
FAU - Kang, Do-Hyung
AU  - Kang DH
AD  - Jeju International Marine Science Center for Research & Education, Korea 
      Institute of Ocean Science & Technology (KIOST), Jeju 63349, Korea. 
      dohkang@kiost.ac.kr.
FAU - Kim, Kui-Jin
AU  - Kim KJ
AD  - Department of Food Science and Biotechnology, College of Life Science, CHA 
      University, Seongnam, Kyonggi 13488, Korea. Kuijin.Kim@cha.ac.kr.
FAU - Lee, Boo-Yong
AU  - Lee BY
AD  - Department of Food Science and Biotechnology, College of Life Science, CHA 
      University, Seongnam, Kyonggi 13488, Korea. bylee@cha.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Extracts)
RN  - 0 (Flavonoids)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Polyphenols)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - CREB-Binding Protein/genetics
MH  - Cell Extracts/*chemistry/pharmacology
MH  - Cell Line
MH  - Flavonoids/chemistry/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Mice
MH  - Neurons/*drug effects/pathology
MH  - Neuroprotective Agents/pharmacology
MH  - Neurotoxicity Syndromes/*drug therapy/pathology
MH  - Poly(ADP-ribose) Polymerases/genetics
MH  - Polyphenols/chemistry/pharmacology
MH  - Signal Transduction/drug effects
MH  - Spirulina/*chemistry
PMC - PMC6151979
OTO - NOTNLM
OT  - Spirulina maxima 70% ethanol extract (SM70EE)
OT  - acetylcholinesterase (AChE)
OT  - cognitive deficits
OT  - neurotoxicity
OT  - trimethyltin (TMT)
COIS- The authors declare no conflict of interest.
EDAT- 2017/08/18 06:00
MHDA- 2018/04/27 06:00
PMCR- 2017/08/17
CRDT- 2017/08/18 06:00
PHST- 2017/07/06 00:00 [received]
PHST- 2017/08/10 00:00 [revised]
PHST- 2017/08/16 00:00 [accepted]
PHST- 2017/08/18 06:00 [entrez]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2017/08/17 00:00 [pmc-release]
AID - molecules22081363 [pii]
AID - molecules-22-01363 [pii]
AID - 10.3390/molecules22081363 [doi]
PST - epublish
SO  - Molecules. 2017 Aug 17;22(8):1363. doi: 10.3390/molecules22081363.