PMID- 28817805
OWN - NLM
STAT- MEDLINE
DCOM- 20170830
LR  - 20240212
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 95
IP  - 4
DP  - 2017 Aug 16
TI  - LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus 
      Output by Increasing Excitation/Inhibition Balance.
PG  - 928-943.e3
LID - S0896-6273(17)30650-5 [pii]
LID - 10.1016/j.neuron.2017.07.028 [doi]
AB  - Excitatory hilar mossy cells (MCs) in the dentate gyrus receive inputs from 
      dentate granule cells (GCs) and project back to GCs locally, contralaterally, and 
      along the longitudinal axis of the hippocampus, thereby establishing an 
      associative positive-feedback loop and connecting functionally diverse 
      hippocampal areas. MCs also synapse with GABAergic interneurons that mediate 
      feed-forward inhibition onto GCs. Surprisingly, although these circuits have been 
      implicated in both memory formation (e.g., pattern separation) and temporal lobe 
      epilepsy, little is known about activity-dependent plasticity of their synaptic 
      connections. Here, we report that MC-GC synapses undergo a presynaptic, 
      NMDA-receptor-independent form of long-term potentiation (LTP) that requires 
      postsynaptic brain-derived neurotrophic factor (BDNF)/TrkB and presynaptic cyclic 
      AMP (cAMP)/PKA signaling. This LTP is input specific and selectively expressed at 
      MC-GC synapses, but not at the disynaptic inhibitory loop. By increasing the 
      excitation/inhibition balance, MC-GC LTP enhances GC output at the associative 
      MC-GC recurrent circuit and may contribute to dentate-dependent forms of learning 
      and epilepsy.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Hashimotodani, Yuki
AU  - Hashimotodani Y
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Nasrallah, Kaoutsar
AU  - Nasrallah K
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Jensen, Kyle R
AU  - Jensen KR
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Chavez, Andres E
AU  - Chavez AE
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Carrera, Daniel
AU  - Carrera D
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA.
FAU - Castillo, Pablo E
AU  - Castillo PE
AD  - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. Electronic address: 
      pablo.castillo@einstein.yu.edu.
LA  - eng
GR  - R01 DA017392/DA/NIDA NIH HHS/United States
GR  - F32 NS071821/NS/NINDS NIH HHS/United States
GR  - T34 GM008718/GM/NIGMS NIH HHS/United States
GR  - R25 GM104547/GM/NIGMS NIH HHS/United States
GR  - R01 MH081935/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Channelrhodopsins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Presynaptic)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Channelrhodopsins
MH  - Dentate Gyrus/*cytology
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Long-Term Synaptic Depression/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Mossy Fibers, Hippocampal/*physiology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/*physiology
MH  - Neurotransmitter Agents/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/genetics/metabolism
MH  - Receptors, Presynaptic/metabolism
MH  - Signal Transduction/drug effects
MH  - Synapses/*physiology
PMC - PMC5609819
MID - NIHMS904217
OTO - NOTNLM
OT  - BDNF
OT  - CA3
OT  - TrkB
OT  - hippocampus
OT  - learning
OT  - memory
OT  - pattern separation
OT  - presynaptic
EDAT- 2017/08/18 06:00
MHDA- 2017/08/31 06:00
PMCR- 2017/09/22
CRDT- 2017/08/18 06:00
PHST- 2017/03/03 00:00 [received]
PHST- 2017/06/23 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/08/18 06:00 [entrez]
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2017/08/31 06:00 [medline]
PHST- 2017/09/22 00:00 [pmc-release]
AID - S0896-6273(17)30650-5 [pii]
AID - 10.1016/j.neuron.2017.07.028 [doi]
PST - ppublish
SO  - Neuron. 2017 Aug 16;95(4):928-943.e3. doi: 10.1016/j.neuron.2017.07.028.