PMID- 28818006
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20180521
IS  - 1552-6844 (Electronic)
IS  - 1545-9683 (Linking)
VI  - 31
IP  - 9
DP  - 2017 Sep
TI  - The Role of the BDNF Val66Met Polymorphism in Recovery of Aphasia After Stroke.
PG  - 851-857
LID - 10.1177/1545968317723752 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is assumed to play a role in 
      mediating neuroplasticity after stroke. Carriers of the function-limiting 
      Val66Met (rs6265) single nucleotide polymorphism (SNP) may have a downregulation 
      in BDNF secretion, which may lead to a poorer prognosis after stroke compared to 
      noncarriers in motor learning and motor function recovery. The present study 
      investigates whether this polymorphism may also affect the recovery of poststroke 
      aphasia (ie, language impairment). OBJECTIVE: To study the influence of the BDNF 
      Val66Met polymorphism on the recovery of poststroke aphasia. METHODS: We included 
      53 patients with poststroke aphasia, all participating in an inpatient 
      rehabilitation program with speech and language therapy. All patients were 
      genotyped for the Val66Met SNP and subdivided into carriers (at least one Met 
      allele) and noncarriers (no Met allele). Primary outcome measures included the 
      improvement over rehabilitation time on the Amsterdam-Nijmegen Everyday Language 
      Test (ANELT) and the Boston Naming Test (BNT). RESULTS: The outcome measures 
      showed a large variability in the improvement scores on both the ANELT and BNT. 
      There was no significant difference between noncarriers and carriers in the 
      primary outcome measures. CONCLUSION: This study investigated the effect of the 
      BDNF Val66Met polymorphism on clinical recovery of poststroke aphasia. In 
      contrast to earlier studies describing a reducing effect of this polymorphism on 
      motor function recovery after stroke, the present study does not support a 
      reduction in language recovery for carriers compared to noncarriers with 
      poststroke aphasia.
FAU - de Boer, Riemke G A
AU  - de Boer RGA
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Spielmann, Kerstin
AU  - Spielmann K
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Heijenbrok-Kal, Majanka H
AU  - Heijenbrok-Kal MH
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - van der Vliet, Rick
AU  - van der Vliet R
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - Ribbers, Gerard M
AU  - Ribbers GM
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
FAU - van de Sandt-Koenderman, W Mieke E
AU  - van de Sandt-Koenderman WME
AD  - 1 Rijndam Rehabilitation, Rotterdam, Netherlands.
AD  - 2 Department of Rehabilitation Medicine, Erasmus MC, University Medical Center 
      Rotterdam, Rotterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aphasia/etiology/genetics/rehabilitation
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Genotype
MH  - Humans
MH  - Language Tests
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Recovery of Function/*genetics
MH  - Retrospective Studies
MH  - Saliva/metabolism
MH  - Stroke/*complications
MH  - *Stroke Rehabilitation
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - aphasia
OT  - brain-derived neurotrophic factor
OT  - neuroplasticity
OT  - single nucleotide polymorphism
OT  - stroke
EDAT- 2017/08/19 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/08/19 06:00
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/08/19 06:00 [entrez]
AID - 10.1177/1545968317723752 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2017 Sep;31(9):851-857. doi: 
      10.1177/1545968317723752. Epub 2017 Aug 17.