PMID- 28818748 OWN - NLM STAT- MEDLINE DCOM- 20180917 LR - 20181202 IS - 1898-4002 (Electronic) IS - 1896-1126 (Linking) VI - 63 IP - 1 DP - 2018 Mar TI - Association of Brain-derived neurotrophic factor gene polymorphisms with body mass index: A systematic review and meta-analysis. PG - 43-56 LID - S1896-1126(17)30053-6 [pii] LID - 10.1016/j.advms.2017.07.002 [doi] AB - BACKGROUND: Many studies with inconsistent results have assessed the association of Brain-derived neurotrophic factor (BDNF) gene polymorphisms with prevalence of obesity and overweight. This review aims to provide a summary of the literature evaluating the relation between BDNF genotype and body mass index (BMI). METHODS: A systematic search through PubMed, Scopus, Science direct, Ovid and Cochrane was performed. We included observational studies with cross-sectional and case-control design, which investigated relationship between all kinds of BDNF polymorphisms with BMI, as a representative index of obesity and overweight. Newcastle-Ottawa Scale was used to assess the quality of included articles. RESULTS: Thirty five studies were included in quantitative synthesis. Analyses were performed separately using OR, beta coefficient and mean. Significant association were documented between rs925946 and BMI (OR=1.12, 95% CI=1.08-1.17, P heterogeneity=0.317), rs10501087 and BMI (OR=1.14, 95% CI=1.04-1.24, P heterogeneity=0.861), rs6265 and BMI (OR=1.13, 95% CI=1.07-1.19, P heterogeneity=0.406), rs988712 and BMI (OR=1.29, 95% CI=1.18-1.40, P heterogeneity=0.602). According to pooled beta coefficient analysis, significant result was only observed in the rs925946 polymorphism subgroup. Pooled mean analysis showed that overall effects for the association between BDNF polymorphisms and BMI were not statistically significant. CONCLUSION: This meta-analysis suggests that some polymorphisms in BDNF gene including rs925946, rs10501087, rs6265 and rs988712 can be considered as genetic determinants of obesity. CI - Copyright (c) 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved. FAU - Akbarian, Shahab-Aldin AU - Akbarian SA AD - Food Security Research Center, Department of Community nutrition, School of Nutrition & Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Salehi-Abargouei, Amin AU - Salehi-Abargouei A AD - Department of nutrition, faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Pourmasoumi, Makan AU - Pourmasoumi M AD - Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Nikpour, Parvaneh AU - Nikpour P AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Heidari-Beni, Motahar AU - Heidari-Beni M AD - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: motahar.heidari@nutr.mui.ac.ir. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20171201 PL - Netherlands TA - Adv Med Sci JT - Advances in medical sciences JID - 101276222 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - *Body Mass Index MH - Brain-Derived Neurotrophic Factor/*genetics MH - *Genetic Association Studies MH - Humans MH - Odds Ratio MH - *Polymorphism, Genetic MH - Publication Bias OTO - NOTNLM OT - Body mass index OT - Brain-derived neurotrophic factor OT - Meta-analysis OT - Single nucleotide polymorphisms EDAT- 2017/08/19 06:00 MHDA- 2018/09/18 06:00 CRDT- 2017/08/19 06:00 PHST- 2017/02/28 00:00 [received] PHST- 2017/07/04 00:00 [revised] PHST- 2017/07/18 00:00 [accepted] PHST- 2017/08/19 06:00 [pubmed] PHST- 2018/09/18 06:00 [medline] PHST- 2017/08/19 06:00 [entrez] AID - S1896-1126(17)30053-6 [pii] AID - 10.1016/j.advms.2017.07.002 [doi] PST - ppublish SO - Adv Med Sci. 2018 Mar;63(1):43-56. doi: 10.1016/j.advms.2017.07.002. Epub 2017 Dec 1.