PMID- 28819165
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20240326
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 17
TI  - ATP-sensitive inwardly rectifying potassium channel regulation of viral 
      infections in honey bees.
PG  - 8668
LID - 10.1038/s41598-017-09448-y [doi]
LID - 8668
AB  - Honey bees are economically important pollinators of a wide variety of crops that 
      have attracted the attention of both researchers and the public alike due to 
      unusual declines in the numbers of managed colonies in some parts of the world. 
      Viral infections are thought to be a significant factor contributing to these 
      declines, but viruses have proven a challenging pathogen to study in a bee model 
      and interactions between viruses and the bee antiviral immune response remain 
      poorly understood. In the work described here, we have demonstrated the use of 
      flock house virus (FHV) as a model system for virus infection in bees and 
      revealed an important role for the regulation of the bee antiviral immune 
      response by ATP-sensitive inwardly rectifying potassium (K(ATP)) channels. We 
      have shown that treatment with the K(ATP) channel agonist pinacidil increases 
      survival of bees while decreasing viral replication following infection with FHV, 
      whereas treatment with the K(ATP) channel antagonist tolbutamide decreases 
      survival and increases viral replication. Our results suggest that K(ATP) 
      channels provide a significant link between cellular metabolism and the antiviral 
      immune response in bees.
FAU - O'Neal, Scott T
AU  - O'Neal ST
AUID- ORCID: 0000-0002-2745-1712
AD  - Department of Entomology, Virginia Tech, Blacksburg, VA, USA. onealst@vt.edu.
FAU - Swale, Daniel R
AU  - Swale DR
AD  - Department of Entomology, Louisiana State University AgCenter, Baton Rouge, LA, 
      USA.
FAU - Anderson, Troy D
AU  - Anderson TD
AD  - Department of Entomology, University of Nebraska, Lincoln, NE, USA. 
      tanderson44@unl.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170817
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Animal Diseases/*metabolism/*virology
MH  - Animals
MH  - Bees/*metabolism/*virology
MH  - *Host-Pathogen Interactions
MH  - Ion Channel Gating/drug effects
MH  - Potassium Channels, Inwardly Rectifying/agonists/antagonists & 
      inhibitors/*metabolism
MH  - Virus Diseases/*veterinary
PMC - PMC5561242
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/19 06:00
MHDA- 2019/03/16 06:00
PMCR- 2017/08/17
CRDT- 2017/08/19 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/08/19 06:00 [entrez]
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2017/08/17 00:00 [pmc-release]
AID - 10.1038/s41598-017-09448-y [pii]
AID - 9448 [pii]
AID - 10.1038/s41598-017-09448-y [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 17;7(1):8668. doi: 10.1038/s41598-017-09448-y.