PMID- 28819238
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20191210
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 17
TI  - Effects of environmental enrichment upon ethanol-induced conditioned place 
      preference and pre-frontal BDNF levels in adolescent and adult mice.
PG  - 8574
LID - 10.1038/s41598-017-08795-0 [doi]
LID - 8574
AB  - Environmental enrichment (EE) provides a non-pharmacological tool to alter 
      drug-induced reward, yet its effects on ethanol-induced reward remain 
      controversial. We analyzed adolescent vs. adult (mice) differences in the 
      influence of EE on ethanol-induced conditioned place preference (CPP). The 
      effects of these treatments on brain-derived neurotrophic factor (BDNF) levels in 
      the prefrontal cortex were examined in a separate group of animals. 
      Ethanol-induced CPP was found in adults, and it was similar in EE and in animals 
      reared under standard housing conditions (SC). Adolescents kept under EE, but not 
      those in SC, exhibited CPP. Among SC, but not among EE, adolescents, BDNF levels 
      were significantly lower in those treated with ethanol than in those given 
      vehicle. These results indicate that, compared to adults, adolescent exhibited 
      reduced sensitivity to ethanol's rewarding effects, yet the youth but not the 
      adults exhibited sensitivity to the promoting effect of EE upon CPP by ethanol. 
      Ethanol significantly reduced BDNF levels in adolescents reared under standard 
      housing conditions, but not in adult mice nor in adolescents given EE housing 
      conditions. The present results add to the plethora of adolescent-specific 
      responses to ethanol or to environmental stimuli that may put the youth at risk 
      for escalation of ethanol intake.
FAU - Pautassi, Ricardo Marcos
AU  - Pautassi RM
AUID- ORCID: 0000-0003-1876-2321
AD  - Instituto de Investigacion Medica M. y M. Ferreyra (INIMEC-CONICET-UNC), Cordoba, 
      Argentina. rpautassi@gmail.com.
AD  - Facultad de Psicologia, Universidad Nacional de Cordoba, Cordoba, C.P., 5000, 
      Argentina. rpautassi@gmail.com.
FAU - Suarez, Andrea B
AU  - Suarez AB
AD  - Laboratorio de Psicologia Experimentaly Aplicada, IDIM, CONICET, UBA, Buenos 
      Aires, Argentina.
FAU - Hoffmann, Lucas Barbosa
AU  - Hoffmann LB
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Rueda, Andre Veloso
AU  - Rueda AV
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Rae, Mariana
AU  - Rae M
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Marianno, Priscila
AU  - Marianno P
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Camarini, Rosana
AU  - Camarini R
AUID- ORCID: 0000-0002-8131-6108
AD  - Departamento de Farmacologia, Instituto de Ciencias Biomedicas, Universidade de 
      Sao Paulo, Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170817
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Age Factors
MH  - Alcohol Drinking
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Depressants/administration & dosage/pharmacology
MH  - Conditioning, Psychological/*drug effects/physiology
MH  - Environment
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Mice
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Reward
MH  - Space Perception/drug effects/physiology
PMC - PMC5561235
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/19 06:00
MHDA- 2019/03/26 06:00
PMCR- 2017/08/17
CRDT- 2017/08/19 06:00
PHST- 2017/03/07 00:00 [received]
PHST- 2017/07/18 00:00 [accepted]
PHST- 2017/08/19 06:00 [entrez]
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2017/08/17 00:00 [pmc-release]
AID - 10.1038/s41598-017-08795-0 [pii]
AID - 8795 [pii]
AID - 10.1038/s41598-017-08795-0 [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 17;7(1):8574. doi: 10.1038/s41598-017-08795-0.