PMID- 28819445
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 8
IP  - 12
DP  - 2017
TI  - DNA-dependent protein kinase catalytic subunit functions in metastasis and 
      influences survival in advanced-stage laryngeal squamous cell carcinoma.
PG  - 2410-2416
LID - 10.7150/jca.20069 [doi]
AB  - Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is known to 
      function in several types of cancer. In this study, we investigated the 
      expression and clinicopathologic significance of DNA-PKcs in laryngeal squamous 
      cell carcinoma (LSCC). Methods: We conducted a retrospective study of 208 
      patients with advanced-stage LSCC treated at Sun Yat-sen University Cancer 
      Center, Guangzhou, China. We assessed DNA-PKcs and p16INK4a (p16) status using 
      immunohistochemistry. We examined the association between DNA-PKcs expression and 
      clinicopathologic features and survival outcomes. To evaluate the independent 
      prognostic relevance of DNA-PKcs, we used univariate and multivariate Cox 
      regression models. We estimated overall survival (OS) and distant metastasis-free 
      survival (DMFS) using the Kaplan-Meier method. Results: Immunohistochemical 
      analyses revealed that 163/208 (78.4%) of the LSCC tissue samples exhibited high 
      DNA-PKcs expression. High DNA-PKcs expression was significantly associated with 
      survival outcomes (P = 0.016) and distant metastasis (P = 0.02; chi-squared 
      test). High DNA-PKcs expression was associated with a significantly shorter OS 
      and DMFS than low DNA-PKcs expression (P = 0.029 and 0.033, respectively; 
      log-rank test), and was associated with poor OS in the p16-positive subgroup (P = 
      0.047). Multivariate analysis identified DNA-PKcs as an independent prognostic 
      indicator of OS and DMFS in all patients (P = 0.039 and 0.037, respectively). 
      Conclusions: Our results suggest that patients with LSCC in whom DNA-PKcs 
      expression is elevated have a higher incidence of distant metastasis and a poorer 
      prognosis. DNA-PKcs may represent a marker of tumor progression in patients with 
      p16-positive LSCC.
FAU - He, Sha-Sha
AU  - He SS
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Radiation, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
FAU - Chen, Yong
AU  - Chen Y
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Radiation, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
FAU - Shen, Xiao-Ming
AU  - Shen XM
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Radiology, The First People's Hospital of Foshan (The affiliated 
      Foshan Hospital of Sun Yat-Sen University), Foshan, Guangdong, China.
FAU - Wang, Hong-Zhi
AU  - Wang HZ
AD  - Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical 
      Science, Peking Union Medical College, Beijing 100021, China.
FAU - Sun, Peng
AU  - Sun P
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
FAU - Dong, Jun
AU  - Dong J
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Guo, Gui-Fang
AU  - Guo GF
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Chen, Ju-Gao
AU  - Chen JG
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
FAU - Xia, Liang-Ping
AU  - Xia LP
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Hu, Pei-Li
AU  - Hu PL
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Qiu, Hui-Juan
AU  - Qiu HJ
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Liu, Shou-Sheng
AU  - Liu SS
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Zhou, Yi-Xin
AU  - Zhou YX
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Wang, Wei
AU  - Wang W
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Gastric Surgery, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Hu, Wei-Han
AU  - Hu WH
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of Radiation, Cancer Center, Sun Yat-Sen University, Guangzhou, China.
FAU - Cai, Xiu-Yu
AU  - Cai XY
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen 
      University, Guangzhou.
AD  - Department of VIP Region, Cancer Center, Sun Yat-Sen University, Guangzhou, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170722
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC5560160
OTO - NOTNLM
OT  - DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
OT  - Laryngeal squamous cell carcinoma
OT  - p16INK4a (p16)
OT  - prognosis
COIS- Competing Interests: The authors declare that there are no conflicts of interest 
      relevant to this article.
EDAT- 2017/08/19 06:00
MHDA- 2017/08/19 06:01
PMCR- 2017/01/01
CRDT- 2017/08/19 06:00
PHST- 2017/03/14 00:00 [received]
PHST- 2017/05/18 00:00 [accepted]
PHST- 2017/08/19 06:00 [entrez]
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2017/08/19 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - jcav08p2410 [pii]
AID - 10.7150/jca.20069 [doi]
PST - epublish
SO  - J Cancer. 2017 Jul 22;8(12):2410-2416. doi: 10.7150/jca.20069. eCollection 2017.