PMID- 28819713
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20181202
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 38
IP  - 8
DP  - 2017 Dec
TI  - Plasma Growth Differentiation Factor-15 is a Potential Biomarker for Pediatric 
      Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.
PG  - 1620-1626
LID - 10.1007/s00246-017-1705-7 [doi]
AB  - We aimed to investigate plasma growth differentiation factor-15 (GDF-15) levels 
      in pediatric pulmonary arterial hypertension secondary to congenital heart 
      disease (PAH-CHD), and assess the association with hemodynamic parameters. Plasma 
      GDF-15 levels were measured in children with PAH-CHD (n = 46) and compared to 
      children with CHD without PAH (n = 39). Normal individuals (n = 30) served as 
      health control group. Plasma GDF-15 levels were significantly elevated in 
      patients with PAH-CHD compared with those with CHD without PAH (median 1415 ng/L, 
      interquartile range [IQR] 926.7-2111.7 ng/L vs. 890.6 ng/L, IQR 
      394.7-1094.3 ng/L, p < 0.01). Elevated plasma GDF-15 levels were positively 
      related to Functional Class, uric acid, N-terminal pro-B-type natriuretic peptide 
      (NT-proBNP), pulmonary artery systolic pressure, mean pulmonary artery pressure, 
      pulmonary blood flow/systemic blood flow and pulmonary vascular resistance, and a 
      lower mixed venous oxygen saturation (Sv(o2)). The area under the curve (AUC) for 
      adding GDF-15 to NT-proBNP was not superior to the AUC of NT-pro BNP alone (AUC 
      difference 0.0295, p = 0.324) (NT-proBNP, AUC 0.823, 95% CI 0.725-0.897; GDF-15 
      plus NT-proBNP, AUC 0.852, 95% CI 0.759-0.92), whereas it revealed a slightly 
      greater specificity and positive predictive value. The diagnostic power of NT-pro 
      BNP was not inferior to GDF-15 (AUC difference 0.0443, p = 0.43). Plasma GDF-15 
      levels might be a surrogate marker for pediatric PAH-CHD.
FAU - Li, Gang
AU  - Li G
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Li, Yan
AU  - Li Y
AD  - Medical Research Center, The Affiliated Hospital of Southwest Medical University, 
      NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Tan, Xiao-Qiu
AU  - Tan XQ
AD  - Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative 
      Innovation Center for Prevention and Treatment of Cardiovascular 
      Disease/Institute of Cardiovascular Research, Southwest Medical University, 
      Luzhou, 646000, China.
FAU - Jia, Peng
AU  - Jia P
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Zhao, Jian
AU  - Zhao J
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Liu, Dong
AU  - Liu D
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Wang, Ting
AU  - Wang T
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
FAU - Liu, Bin
AU  - Liu B
AD  - Department of Pediatrics, The Affiliated Hospital of Southwest Medical 
      University, NO. 25 Taiping Street, Luzhou, 646000, Sichuan, China. 
      lblyfy@126.com.
LA  - eng
GR  - 2016/Talent Foundation of Southwest Medical University/
PT  - Journal Article
DEP - 20170818
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (Biomarkers)
RN  - 0 (GDF15 protein, human)
RN  - 0 (Growth Differentiation Factor 15)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Cardiac Catheterization/methods
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Growth Differentiation Factor 15/*blood
MH  - Heart Defects, Congenital/blood/*complications
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Hypertension, Pulmonary/*blood/diagnosis/etiology
MH  - Infant
MH  - Male
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Biomarker
OT  - Children
OT  - Congenital heart disease
OT  - Growth differentiation factor-15
OT  - Pulmonary arterial hypertension
EDAT- 2017/08/19 06:00
MHDA- 2018/07/11 06:00
CRDT- 2017/08/19 06:00
PHST- 2016/09/10 00:00 [received]
PHST- 2017/08/07 00:00 [accepted]
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/08/19 06:00 [entrez]
AID - 10.1007/s00246-017-1705-7 [pii]
AID - 10.1007/s00246-017-1705-7 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2017 Dec;38(8):1620-1626. doi: 10.1007/s00246-017-1705-7. Epub 
      2017 Aug 18.