PMID- 28820391
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20180509
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 68
IP  - 3
DP  - 2017 Jun
TI  - Deep brain stimulation alters light phase food intake microstructure in rats.
PG  - 345-354
AB  - Treatment of eating disorders like obesity or anorexia is challenging. Options 
      are limited and new approaches desired. An interesting approach is the 
      application of deep brain stimulation (DBS). The nucleus accumbens (NAcc) is part 
      of the food reward system. A pilot study reported that DBS of the NAcc shell 
      modulates food intake and body weight in rats. Underlying mechanisms such as the 
      food intake microstructure are unknown so far. Normal weight female 
      Sprague-Dawley rats were equipped with a custom-made DBS electrode placed 
      unilaterally in the NAcc shell. Biphasic stimulation was performed for seven 
      days. Body weight and food intake including the microstructure were assessed over 
      the experimental period. Behavior was monitored manually. DBS tended to increase 
      body weight gain (28.1 +/- 5.4 g) compared to sham-stimulated controls (16.7 +/- 3.4, 
      P = 0.05) without affecting daily food intake (P > 0.05). Further analyses showed 
      that light phase food intake was stimulated, whereas dark phase food intake was 
      decreased in the DBS group (P < 0.05). During the light phase bout frequency 
      (+50%), bout duration (+64%), meal duration (+71%) and overall time spent in 
      meals (+92%) were increased in DBS rats (P < 0.05), while during the dark phase 
      no alterations were observed (P > 0.05). Behavior did not show differences 
      regarding overall eating and drinking behavior (including food/water approach), 
      grooming or locomotion (P > 0.05). Summarized, although overall food intake was 
      not changed by DBS, light phase food intake was stimulated likely via a reduction 
      of satiation.
FAU - Prinz, P
AU  - Prinz P
AD  - Charite Center for Internal Medicine and Dermatology, Department for 
      Psychosomatic Medicine; Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt - Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany.
FAU - Kobelt, P
AU  - Kobelt P
AD  - Charite Center for Internal Medicine and Dermatology, Department for 
      Psychosomatic Medicine; Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt - Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany.
FAU - Scharner, S
AU  - Scharner S
AD  - Charite Center for Internal Medicine and Dermatology, Department for 
      Psychosomatic Medicine; Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt - Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany.
FAU - Goebel-Stengel, M
AU  - Goebel-Stengel M
AD  - Department of Internal Medicine, Helios Clinic, Zerbst, Germany.
FAU - Harnack, D
AU  - Harnack D
AD  - Clinic for Neurology, Epilepsy Center Berlin-Brandenburg, Beelitz, Germany.
FAU - Faust, K
AU  - Faust K
AD  - Clinic for Neurosurgery, Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany.
FAU - Winter, Y
AU  - Winter Y
AD  - Cognitive Neurobiology, Berlin Mouse Clinic for Neurology and Psychiatry, 
      Humboldt University, Berlin, Germany.
FAU - Rose, M
AU  - Rose M
AD  - Charite Center for Internal Medicine and Dermatology, Department for 
      Psychosomatic Medicine; Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt - Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany.
AD  - Department of Quantitative Health Sciences, Medical School University of 
      Massachusetts, Worcester, Massachusetts, USA.
FAU - Stengel, A
AU  - Stengel A
AD  - Charite Center for Internal Medicine and Dermatology, Department for 
      Psychosomatic Medicine; Charite - Universitaetsmedizin Berlin, corporate member 
      of Freie Universitaet Berlin, Humboldt - Universitaet zu Berlin, and Berlin 
      Institute of Health, Berlin, Germany. andreas.stengel@charite.de.
AD  - Department of Psychosomatic Medicine and Psychotherapy, University Hospital 
      Tuebingen, Tuebingen, Germany.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - *Deep Brain Stimulation
MH  - Eating/*physiology
MH  - Female
MH  - Nucleus Accumbens/*physiology
MH  - Rats, Sprague-Dawley
EDAT- 2017/08/19 06:00
MHDA- 2018/05/10 06:00
CRDT- 2017/08/19 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/05/31 00:00 [accepted]
PHST- 2017/08/19 06:00 [entrez]
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2017 Jun;68(3):345-354.