PMID- 28820685
OWN - NLM
STAT- MEDLINE
DCOM- 20171025
LR  - 20181113
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 4
DP  - 2017 Oct
TI  - Immune Reconstitution Inflammatory Syndrome in HIV-Infected Immigrants.
PG  - 1072-1077
LID - 10.4269/ajtmh.16-0773 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) includes a group of 
      potentially serious inflammatory processes that may be present in HIV-infected 
      patients after initiating highly active antiretroviral therapy (HAART). 
      Paradoxical IRIS is a worsening of symptoms, after an overwhelming response to a 
      previously diagnosed opportunistic infection (OI); unmasking IRIS reveals a 
      previously occult OI. The main objective of the study was to describe the 
      epidemiological, clinical, and outcome data of HIV-infected immigrants, 
      stratified according to high- or low-income countries of origin, who developed 
      IRIS and to compare them with native-born Spanish patients. This retrospective 
      study reviewed all patients with HIV infection admitted to the Unit of Infectious 
      Diseases and Tropical Medicine between 1998 and 2014. IRIS was identified in 
      25/138 (18%) immigrant patients and 24/473 (5%) native-born Spanish patients 
      infected with HIV. Most cases, 19/25 (76%), were of unmasking IRIS. The time 
      elapsed between initiation of HAART and development of IRIS was significantly 
      longer in patients with unmasking versus paradoxical IRIS. OIs, in particular due 
      to mycobacteria, were the most frequently involved processes. Twenty percent of 
      patients died. The comparison of immigrant and native-born patients found 
      significant differences for both IRIS type (higher incidence of paradoxical forms 
      among immigrants) and for the absence of malignancies in native-born patients. No 
      significant differences were found when the data of immigrants from low- and 
      high-income countries were compared.
FAU - Perez-Rueda, Maria
AU  - Perez-Rueda M
AD  - Internal Medicine, Hospital San Roque Maspalomas (HSRM), Gran Canaria, Spain.
FAU - Hernandez-Cabrera, Michele
AU  - Hernandez-Cabrera M
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
AD  - Department of Medical and Surgical Sciences, University of Las Palmas, Las 
      Palmas, Spain.
FAU - Frances-Urmeneta, Adela
AU  - Frances-Urmeneta A
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
FAU - Angel-Moreno, Alfonso
AU  - Angel-Moreno A
AD  - Internal Medicine, Puerta de Hierro Hospital, Madrid, Spain.
FAU - Pisos-Alamo, Elena
AU  - Pisos-Alamo E
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
AD  - Department of Medical and Surgical Sciences, University of Las Palmas, Las 
      Palmas, Spain.
FAU - Jaen-Sanchez, Nieves
AU  - Jaen-Sanchez N
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
AD  - Department of Medical and Surgical Sciences, University of Las Palmas, Las 
      Palmas, Spain.
FAU - Carranza-Rodriguez, Cristina
AU  - Carranza-Rodriguez C
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
AD  - Department of Medical and Surgical Sciences, University of Las Palmas, Las 
      Palmas, Spain.
FAU - Perez-Arellano, Jose-Luis
AU  - Perez-Arellano JL
AD  - Department of Medical and Surgical Sciences, University of Las Palmas, Las 
      Palmas, Spain.
AD  - Unit of Infectious Diseases and Tropical Medicine, Hospital Universitario Insular 
      de Gran Canaria (HUIGC), Las Palmas, Spain.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170818
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*drug therapy/epidemiology/*etiology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-HIV Agents/*therapeutic use
MH  - Emigrants and Immigrants/*statistics & numerical data
MH  - Female
MH  - HIV Infections/*complications/epidemiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy/epidemiology/*etiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Spain/epidemiology
PMC - PMC5637585
EDAT- 2017/08/19 06:00
MHDA- 2017/10/27 06:00
PMCR- 2018/10/11
CRDT- 2017/08/19 06:00
PHST- 2017/08/19 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/08/19 06:00 [entrez]
PHST- 2018/10/11 00:00 [pmc-release]
AID - tpmd160773 [pii]
AID - 10.4269/ajtmh.16-0773 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Oct;97(4):1072-1077. doi: 10.4269/ajtmh.16-0773. Epub 
      2017 Aug 18.