PMID- 28821114
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180220
LR  - 20180220
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 174
DP  - 2017 Oct 15
TI  - Preparation and characterization of a composite biomaterial including starch 
      micro/nano particles loaded chitosan gel.
PG  - 633-645
LID - S0144-8617(17)30732-4 [pii]
LID - 10.1016/j.carbpol.2017.06.095 [doi]
AB  - Thermosensitive Chitosan hydrogels which can be injected into defects with 
      minimally invasive approach were prepared. Also starch micro/nano particles were 
      synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles 
      were incorporated into the chitosan hydrogel to prepare injectable 
      thermosensitive hydrogel composites. Tube inverting method, compression tests, 
      swelling studies, XRD, SEM, OM, DLS, UV-vis spectroscopy were used for 
      investigations. Results revealed that increasing crosslinker and surfactant 
      contents and stirring rate leads to particle size reduction. Particle size was 
      modeled using design of experiments (DOE) via the response surface method (RSM). 
      Due to analysis of variance (ANOVA), the particle sizes can be predicted by 
      quadratic model within the design space. Gelation time and compressive modulus 
      measurements showed the particles significant influence on the blend network 
      density and hydrogel mechanical properties. Swelling measurements revealed that 
      incorporation of starch particles in chitosan hydrogel increases its swelling 
      coefficient significantly. The innovative architecture, namely micro/nano 
      particles in gel can be considered as a dual delivery platform or smart scaffold 
      for engineering of certain tissues.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Dehghan Baniani, Dorsa
AU  - Dehghan Baniani D
AD  - Polymeric Materials Research Group, Department of Materials Science and 
      Engineering, Sharif University of Technology, Tehran, P.O. Box 11155-9466, Iran. 
      Electronic address: dehghanbaniani_d@mehr.sharif.edu.
FAU - Bagheri, Reza
AU  - Bagheri R
AD  - Polymeric Materials Research Group, Department of Materials Science and 
      Engineering, Sharif University of Technology, Tehran, P.O. Box 11155-9466, Iran. 
      Electronic address: rezabagh@sharif.edu.
FAU - Solouk, Atefeh
AU  - Solouk A
AD  - Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 
      Iran. Electronic address: atefeh.solouk@aut.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20170624
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
OTO - NOTNLM
OT  - AHP (Pubchem CID: 24402)
OT  - Acetic acid (Pubchem CID: 176)
OT  - Acetone (Pubchem CID: 180)
OT  - Chitosan (Pubchem CID: 71853)
OT  - Compressive modulus
OT  - Design of experiments (DOE)
OT  - Hydrogel composites
OT  - Methylene blue (Pubchem CID: 6099)
OT  - Micro/nano particles
OT  - Phosphate buffered saline (Pubchem CID: 24978514)
OT  - Sodium chloride (Pubchem CID: 5234)
OT  - Sodium hydroxide (Pubchem CID: 14798)
OT  - Span 80 (Pubchem CID: 5385498)
OT  - Starch
OT  - Starch (Pubchem CID: 439341)
OT  - Surface response method
OT  - Thermosensitive chitosan hydrogel
OT  - Trisodium trimeta phosphate (Pubchem CID: 24579)
OT  - Tween 80 (Pubchem CID: 5281955)
EDAT- 2017/08/20 06:00
MHDA- 2017/08/20 06:01
CRDT- 2017/08/20 06:00
PHST- 2017/01/24 00:00 [received]
PHST- 2017/05/17 00:00 [revised]
PHST- 2017/06/22 00:00 [accepted]
PHST- 2017/08/20 06:00 [entrez]
PHST- 2017/08/20 06:00 [pubmed]
PHST- 2017/08/20 06:01 [medline]
AID - S0144-8617(17)30732-4 [pii]
AID - 10.1016/j.carbpol.2017.06.095 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Oct 15;174:633-645. doi: 10.1016/j.carbpol.2017.06.095. 
      Epub 2017 Jun 24.