PMID- 28821448
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20200930
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 180
DP  - 2017 Oct 15
TI  - Cognitive impairment and gene expression alterations in a rodent model of binge 
      eating disorder.
PG  - 78-90
LID - S0031-9384(17)30251-2 [pii]
LID - 10.1016/j.physbeh.2017.08.004 [doi]
AB  - Binge eating disorder (BED) is defined as recurrent, distressing over-consumption 
      of palatable food (PF) in a short time period. Clinical studies suggest that 
      individuals with BED may have impairments in cognitive processes, executive 
      functioning, impulse control, and decision-making, which may play a role in 
      sustaining binge eating behavior. These clinical reports, however, are limited 
      and often conflicting. In this study, we used a limited access rat model of 
      binge-like behavior in order to further explore the effects of binge eating on 
      cognition. In binge eating prone (BEP) rats, we found novel object recognition 
      (NOR) as well as Barnes maze reversal learning (BM-RL) deficits. Aberrant gene 
      expression of brain derived neurotrophic factor (Bdnf) and tropomyosin receptor 
      kinase B (TrkB) in the hippocampus (HPC)-prefrontal cortex (PFC) network was 
      observed in BEP rats. Additionally, the NOR deficits were correlated with 
      reductions in the expression of TrkB and insulin receptor (Ir) in the CA3 region 
      of the hippocampus. Furthermore, up-regulation of serotonin-2C (5-HT(2C)) 
      receptors in the orbitoprefrontal cortex (OFC) was associated with BM-RL deficit. 
      Finally, in the nucleus accumbens (NAc), we found decreased dopamine receptor 2 
      (Drd2) expression among BEP rats. Taken together, these data suggest that binge 
      eating vegetable shortening may induce contextual and reversal learning deficits 
      which may be mediated, at least in part, by the altered expression of genes in 
      the CA3-OFC-NAc neural network.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Chawla, Anjali
AU  - Chawla A
AD  - Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD 21205, United States.
FAU - Cordner, Zachary A
AU  - Cordner ZA
AD  - Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD 21205, United States.
FAU - Boersma, Gretha
AU  - Boersma G
AD  - Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD 21205, United States.
FAU - Moran, Timothy H
AU  - Moran TH
AD  - Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD 21205, United States. Electronic address: 
      tmoran@jhmi.edu.
LA  - eng
GR  - R01 DK019302/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20170815
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DRD2 protein, rat)
RN  - 0 (Fats)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 0 (Receptors, Dopamine D2)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Binge-Eating Disorder/*complications/*physiopathology
MH  - Body Weight
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cognition Disorders/*etiology
MH  - Disease Models, Animal
MH  - Eating/physiology
MH  - Exploratory Behavior/physiology
MH  - Fats/metabolism
MH  - Gene Expression Regulation/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Insulin/genetics/metabolism
MH  - Receptor, Serotonin, 5-HT2C/genetics/metabolism
MH  - Receptor, trkB/genetics/metabolism
MH  - Receptors, Dopamine D2/genetics/metabolism
MH  - Recognition, Psychology/physiology
PMC - PMC5597488
MID - NIHMS901259
OTO - NOTNLM
OT  - Bdnf
OT  - Binge eating
OT  - Cognition
OT  - High fat
OT  - Serotonin receptor
OT  - TrkB
COIS- DISCLOSURES The authors have no conflicts of interest to declare.
EDAT- 2017/08/20 06:00
MHDA- 2018/05/15 06:00
PMCR- 2018/10/15
CRDT- 2017/08/20 06:00
PHST- 2017/05/03 00:00 [received]
PHST- 2017/08/10 00:00 [revised]
PHST- 2017/08/11 00:00 [accepted]
PHST- 2017/08/20 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/08/20 06:00 [entrez]
PHST- 2018/10/15 00:00 [pmc-release]
AID - S0031-9384(17)30251-2 [pii]
AID - 10.1016/j.physbeh.2017.08.004 [doi]
PST - ppublish
SO  - Physiol Behav. 2017 Oct 15;180:78-90. doi: 10.1016/j.physbeh.2017.08.004. Epub 
      2017 Aug 15.