PMID- 28821721 OWN - NLM STAT- MEDLINE DCOM- 20190318 LR - 20190318 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 7 IP - 1 DP - 2017 Aug 18 TI - Evaluation of the safe use and dietary risk of beta-cypermethrin, pyriproxyfen, avermectin, diflubenzuron and chlorothalonil in button mushroom. PG - 8694 LID - 10.1038/s41598-017-07860-y [doi] LID - 8694 AB - In this study, the residues of beta-cypermethrin, pyriproxyfen, avermectin, diflubenzuron and chlorothalonil in button mushrooms were investigated. The dietary risks of ingesting button mushrooms that have had these pesticides applied by two different methods under normal plant conditions were evaluated. The dissipation of these pesticides into the soil was also studied. According to the maximum residue limits (MRLs) and acceptable daily intakes (ADIs), the final residues of beta-cypermethrin, pyriproxyfen, avermectin, diflubenzuron, and chlorothalonil were safe for human consumption after these pesticides were applied by spraying 2 times at the dosages of 900, 750, 540, 562.5, and 540 g a.i.ha(-1). The dissipation experiment results demonstrated that these pesticides dissipated rapidly after spraying, and there were no residues that could be detected at harvest time when the pesticides were mixed with substrates. According to this work, the application methods of spraying and incorporation with these pesticides at 1 and 1.5 times of the recommended dosage are safe and proper in cultivating button mushrooms. FAU - Du, Pengqiang AU - Du P AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. AD - College of Chemistry, Central China Normal University, No. 152 Luoyu Road, Wuhan, 430079, China. FAU - Wu, Xiaohu AU - Wu X AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. FAU - He, Hairong AU - He H AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. AD - College of Life Science, Northeast Agricultural University, Mucai Street Xiangfang District No. 59, Harbin, 150030, China. FAU - Zhang, Ying AU - Zhang Y AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. AD - Guizhou Institute of Plant Protection, Guizhou, 55000, China. FAU - Xu, Jun AU - Xu J AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. FAU - Dong, Fengshou AU - Dong F AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. FAU - Zheng, Yongquan AU - Zheng Y AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. FAU - Liu, Xingang AU - Liu X AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. liuxingang@caas.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170818 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Nitriles) RN - 0 (Pesticide Residues) RN - 0 (Pyrethrins) RN - 0 (Pyridines) RN - 0 (Soil) RN - 0 (Solvents) RN - 1TR49121NP (cypermethrin) RN - 3Q9VOR705O (pyriproxyfen) RN - 70288-86-7 (Ivermectin) RN - 73989-17-0 (avermectin) RN - J718M71A7A (tetrachloroisophthalonitrile) RN - J76U6ZSI8D (Diflubenzuron) SB - IM MH - Agaricus/*chemistry MH - Calibration MH - *Diet MH - Diflubenzuron/*analysis MH - Half-Life MH - Ivermectin/*analogs & derivatives/analysis MH - Limit of Detection MH - Nitriles/*analysis MH - Pesticide Residues/analysis MH - Pyrethrins/*analysis MH - Pyridines/*analysis MH - Regression Analysis MH - Risk Assessment MH - Risk Factors MH - Soil/chemistry MH - Solvents PMC - PMC5562854 COIS- The authors declare that they have no competing interests. EDAT- 2017/08/20 06:00 MHDA- 2019/03/19 06:00 PMCR- 2017/08/18 CRDT- 2017/08/20 06:00 PHST- 2017/03/02 00:00 [received] PHST- 2017/07/04 00:00 [accepted] PHST- 2017/08/20 06:00 [entrez] PHST- 2017/08/20 06:00 [pubmed] PHST- 2019/03/19 06:00 [medline] PHST- 2017/08/18 00:00 [pmc-release] AID - 10.1038/s41598-017-07860-y [pii] AID - 7860 [pii] AID - 10.1038/s41598-017-07860-y [doi] PST - epublish SO - Sci Rep. 2017 Aug 18;7(1):8694. doi: 10.1038/s41598-017-07860-y.