PMID- 28822116
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20240314
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 55
IP  - 6
DP  - 2018 Jun
TI  - Interactions Between Variation in Candidate Genes and Environmental Factors in 
      the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.
PG  - 5075-5100
LID - 10.1007/s12035-017-0708-y [doi]
AB  - Schizophrenia and bipolar disorder (BD) are complex and multidimensional 
      disorders with high heritability rates. The contribution of genetic factors to 
      the etiology of these disorders is increasingly being recognized as the action of 
      multiple risk variants with small effect sizes, which might explain only a minor 
      part of susceptibility. On the other site, numerous environmental factors have 
      been found to play an important role in their causality. Therefore, in recent 
      years, several studies focused on gene x environment interactions that are 
      believed to bridge the gap between genetic underpinnings and environmental 
      insults. In this article, we performed a systematic review of studies 
      investigating gene x environment interactions in BD and schizophrenia spectrum 
      phenotypes. In the majority of studies from this field, interacting effects of 
      variation in genes encoding catechol-O-methyltransferase (COMT), brain-derived 
      neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) have been 
      explored. Almost consistently, these studies revealed that polymorphisms in COMT, 
      BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or 
      dependence, influencing various outcomes of schizophrenia spectrum disorders and 
      BD. Other interactions still require further replication in larger clinical and 
      non-clinical samples. In addition, future studies should address the direction of 
      causality and potential mechanisms of the relationship between gene x environment 
      interactions and various categories of outcomes in schizophrenia and BD.
FAU - Misiak, Blazej
AU  - Misiak B
AUID- ORCID: 0000-0002-5392-6398
AD  - Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 
      50-368, Wroclaw, Poland. mblazej@interia.eu.
FAU - Stramecki, Filip
AU  - Stramecki F
AD  - Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367, 
      Wroclaw, Poland.
FAU - Gaweda, Lukasz
AU  - Gaweda L
AD  - Department of Psychiatry and Psychotherapy, University Medical Center 
      Hamburg-Eppendorf, Hamburg, Germany.
AD  - II Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
FAU - Prochwicz, Katarzyna
AU  - Prochwicz K
AD  - Institute of Psychology, Jagiellonian University, Krakow, Poland.
FAU - Sasiadek, Maria M
AU  - Sasiadek MM
AD  - Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 
      50-368, Wroclaw, Poland.
FAU - Moustafa, Ahmed A
AU  - Moustafa AA
AD  - School of Social Sciences and Psychology, Marcs Institute of Brain and Behaviour, 
      Western Sydney University, Penrith, NSW, Australia.
FAU - Frydecka, Dorota
AU  - Frydecka D
AD  - Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367, 
      Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20170818
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
SB  - IM
MH  - Bipolar Disorder/*genetics
MH  - *Environment
MH  - *Gene-Environment Interaction
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - Schizophrenia/*genetics
PMC - PMC5948257
OTO - NOTNLM
OT  - Bipolarity
OT  - Gene polymorphism
OT  - Gene x environment interaction
OT  - Psychosis
COIS- The authors declare that they have no conflict of interest.
EDAT- 2017/08/20 06:00
MHDA- 2019/02/05 06:00
PMCR- 2017/08/18
CRDT- 2017/08/20 06:00
PHST- 2016/12/06 00:00 [received]
PHST- 2017/08/01 00:00 [accepted]
PHST- 2017/08/20 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2017/08/20 06:00 [entrez]
PHST- 2017/08/18 00:00 [pmc-release]
AID - 10.1007/s12035-017-0708-y [pii]
AID - 708 [pii]
AID - 10.1007/s12035-017-0708-y [doi]
PST - ppublish
SO  - Mol Neurobiol. 2018 Jun;55(6):5075-5100. doi: 10.1007/s12035-017-0708-y. Epub 
      2017 Aug 18.