PMID- 28822177
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20220410
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 42
IP  - 12
DP  - 2017 Jun
TI  - [Berberine regulates type 2 diabetes mellitus related with insulin resistance].
PG  - 2254-2260
LID - 10.19540/j.cnki.cjcmm.20170307.014 [doi]
AB  - Insulin resistance (IR) is defined as a series of clinical manifestations for 
      diminished effectiveness of insulin in lowering blood sugar levels caused by 
      decreased sensitivity to insulin of liver, muscle and adipose tissue. IR is the 
      major contributor to the etiology and pathogenesis of type 2 diabetes mellitus 
      (T2DM). Berberine, a traditional Chinese herb extract, has been shown to be safe 
      and effective in lowering blood sugar, alleviating insulin resistance and 
      moderating type 2 diabetes mellitus and its complications. The bioavailability of 
      berberine is extremely low, suggesting that it may play a role in lowering blood 
      sugar and lipid by regulating intestinal flora. Intestinal microbiota may serve 
      as a new potential target for berberine treatment of type 2 diabetes mellitus.
CI  - Copyright(c) by the Chinese Pharmaceutical Association.
FAU - Li, Cheng
AU  - Li C
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
AD  - Department of Operative Dentistry and Endodontics, West China Hospital of 
      Stomatology, Sichuan University，Chengdu 610041, China.
FAU - He, Jin-Zhi
AU  - He JZ
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
AD  - Department of Operative Dentistry and Endodontics, West China Hospital of 
      Stomatology, Sichuan University，Chengdu 610041, China.
FAU - Zhou, Xue-Dong
AU  - Zhou XD
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
AD  - Department of Operative Dentistry and Endodontics, West China Hospital of 
      Stomatology, Sichuan University，Chengdu 610041, China.
FAU - Xu, Xin
AU  - Xu X
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, 
      Sichuan University, Chengdu 610041, China.
AD  - Department of Operative Dentistry and Endodontics, West China Hospital of 
      Stomatology, Sichuan University，Chengdu 610041, China.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hypoglycemic Agents)
RN  - 0I8Y3P32UF (Berberine)
SB  - IM
MH  - Berberine/*pharmacology
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - *Insulin Resistance
OTO - NOTNLM
OT  - berberine
OT  - insulin resistance
OT  - intestinal microbiota
OT  - type 2 diabetes mellitus
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2017/08/20 06:00
MHDA- 2018/06/30 06:00
CRDT- 2017/08/20 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/08/20 06:00 [entrez]
PHST- 2017/08/20 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20170307.014 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(12):2254-2260. doi: 
      10.19540/j.cnki.cjcmm.20170307.014.