PMID- 28822835 OWN - NLM STAT- MEDLINE DCOM- 20180726 LR - 20180726 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 658 DP - 2017 Sep 29 TI - Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor. PG - 32-36 LID - S0304-3940(17)30635-3 [pii] LID - 10.1016/j.neulet.2017.07.059 [doi] AB - Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration. Brain-derived neurotrophic factor (BDNF) is a neurotrophin which affects growth, function and survival of neurons, enhances the stabilization of synapses, regulates synaptic function and branching of dendrites and axons. Brain-derived neurotrophic factor is believed to be involved in the pathophysiology of central nervous system (CNS) diseases associated with neuroinflamation. The aim of this study was to investigate new protective and therapeutic effect of acetyl-l-carnitine (ALCAR) in neuroinflammation. Acetyl-l-carnitine was administered into Swiss Albino mice as 100mg/kg/day and 300mg/kg/day for 5days. Neuroinflammation was induced by lipopolysaccharide (LPS). Histopathological findings associated with ALCAR administration on neuroinflammation in the brain were determined. Moreover, the effects of ALCAR on BDNF concentration in the brain tissue was evaluated. The LPS administration showed higher microglial activation in the brain of LPS, 100A+LPS and 300A+LPS groups compared to that in the control (p<0.05). In the 100A+LPS group, microglial activation was lower and BDNF concentration was higher than in the 300A+LPS group (p>0.05). The findings suggest that the dose of ALCAR at 100mg/kg/day i.p. may have a beneficial effect on LPS-induced neuroinflammation in mice. As a conclusion, ALCAR may be used as an optional neuroprotective and therapeutic agent to attenuate inflammatory damage in the CNS regarding BDNF, in a dose dependent manner. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Kazak, Filiz AU - Kazak F AD - Department of Biochemistry, Faculty of Veterinary Medicine, Mustafa Kemal University, Hatay, 31060, Turkey. Electronic address: filizkazak@mku.edu.tr. FAU - Yarim, Gul Fatma AU - Yarim GF AD - Department of Biochemistry, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, 55220, Turkey. LA - eng PT - Journal Article DEP - 20170816 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Lipopolysaccharides) RN - 0 (Neuroprotective Agents) RN - 6DH1W9VH8Q (Acetylcarnitine) SB - IM MH - Acetylcarnitine/*pharmacology MH - Animals MH - Brain/*drug effects/metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Disease Models, Animal MH - Inflammation/drug therapy MH - Lipopolysaccharides/pharmacology MH - Male MH - Mice MH - Neurons/drug effects/metabolism MH - Neuroprotective Agents/*pharmacology OTO - NOTNLM OT - Acetyl-l-carnitine OT - Brain derived neurotrophic factor OT - Lipopolysaccharide OT - Neuroinflammation EDAT- 2017/08/22 06:00 MHDA- 2018/07/27 06:00 CRDT- 2017/08/21 06:00 PHST- 2017/06/21 00:00 [received] PHST- 2017/07/24 00:00 [revised] PHST- 2017/07/31 00:00 [accepted] PHST- 2017/08/22 06:00 [pubmed] PHST- 2018/07/27 06:00 [medline] PHST- 2017/08/21 06:00 [entrez] AID - S0304-3940(17)30635-3 [pii] AID - 10.1016/j.neulet.2017.07.059 [doi] PST - ppublish SO - Neurosci Lett. 2017 Sep 29;658:32-36. doi: 10.1016/j.neulet.2017.07.059. Epub 2017 Aug 16.