PMID- 28823099
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20181113
IS  - 1573-7403 (Electronic)
IS  - 1386-341X (Linking)
VI  - 20
IP  - 6
DP  - 2017 Dec
TI  - Evidence of dysexecutive syndrome in patients with acromegaly.
PG  - 661-667
LID - 10.1007/s11102-017-0831-9 [doi]
AB  - PURPOSE: This study aimed to explore different aspects of executive function in 
      patients with acromegaly and investigate the cause of dysexecutive syndrome in 
      these patients. METHODS: We conducted five typical executive function tests 
      (Stroop test, verbal fluency [VF] test, Hayling Sentence Completion Test [HSCT], 
      N-back test, and Sustained Attention to Response Task [SART]) on 42 acromegalic 
      patients and 42 strictly matched healthy controls. Comparative analyses were 
      conducted for five major executive function domains. The Dysexecutive 
      Questionnaire (DEX) was used to assess patients' subjective feelings about their 
      executive function. All patients underwent a magnetic resonance imaging (MRI) 
      examination and a blood test to determine their pituitary hormone levels before 
      the tests were performed. RESULTS: The patients exhibited worse results on the 
      Stroop test, VF test, HSCT and N-back test compared to the healthy control group. 
      Moreover, part B of the HSCT and the N-back test performance were negatively 
      correlated with IGF-1 concentrations, and the duration of the disease was 
      significantly associated with the Stroop color task results. CONCLUSIONS: 
      Acromegalic patients were severely impaired in semantic inhibition, executive 
      processing, working memory and executive inhibition, and they have realized a 
      portion of these deficits. A high level of IGF-1, disease duration may contribute 
      to the impairment of specific aspects of executive function.
FAU - Shan, Shaobo
AU  - Shan S
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 
      No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      China.
AD  - Center for Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, 
      Beijing, China.
FAU - Fang, Lingling
AU  - Fang L
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 
      No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      China.
AD  - Center for Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, 
      Beijing, China.
FAU - Huang, Jia
AU  - Huang J
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory 
      of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 
      China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Chan, Raymond C K
AU  - Chan RCK
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory 
      of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 
      China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Jia, Guijun
AU  - Jia G
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 
      No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      China.
AD  - Center for Stroke, Beijing Institute for Brain Disorders, Beijing, China.
AD  - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, 
      Beijing, China.
FAU - Wan, Weiqing
AU  - Wan W
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 
      No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China. 
      weiqingwan111@163.com.
AD  - China National Clinical Research Center for Neurological Diseases, Beijing, 
      China. weiqingwan111@163.com.
AD  - Center for Stroke, Beijing Institute for Brain Disorders, Beijing, China. 
      weiqingwan111@163.com.
AD  - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, 
      Beijing, China. weiqingwan111@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pituitary
JT  - Pituitary
JID - 9814578
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Acromegaly/*complications/metabolism/*physiopathology
MH  - Adult
MH  - Cognition Disorders/etiology/metabolism/physiopathology
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - Acromegaly
OT  - Disease duration
OT  - Dysexecutive function
OT  - IGF-1
EDAT- 2017/08/22 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/08/21 06:00
PHST- 2017/08/22 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/08/21 06:00 [entrez]
AID - 10.1007/s11102-017-0831-9 [pii]
AID - 10.1007/s11102-017-0831-9 [doi]
PST - ppublish
SO  - Pituitary. 2017 Dec;20(6):661-667. doi: 10.1007/s11102-017-0831-9.