PMID- 28823317
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20220410
IS  - 2212-4411 (Electronic)
VI  - 124
IP  - 3
DP  - 2017 Sep
TI  - Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a 
      systematic review and meta-analysis study.
PG  - e183-e189
LID - S2212-4403(17)30974-4 [pii]
LID - 10.1016/j.oooo.2017.06.117 [doi]
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) has a role in the progression of the 
      oral lichen planus (OLP). The aim of this meta-analysis study was to evaluate the 
      salivary and serum TNF-alpha levels in patients with OLP. STUDY DESIGN: We searched 
      in the databases of PubMed/Medline, Science direct, Scopus, Web of Science, and 
      Cochrane Library for studies reported from 1983 to 2016. All studies were checked 
      for evaluation of salivary and serum levels of TNF-alpha in patients with OLP 
      compared with healthy controls. RESULTS: Twelve studies were included in the 
      meta-analysis. The mean difference of 7 studies reporting salivary TNF-alpha levels 
      in patients with OLP versus healthy controls was 25.90 pg/mL (95% confidence 
      interval [CI] 15.31-36.49; P < .00001) and 7 studies reporting serum TNF-alpha levels 
      was 1.65 pg/mL (95% CI -0.82 to 4.11; P = .19). CONCLUSIONS: In patients with 
      OLP, the higher levels of TNF-alpha in saliva compared with serum suggest that 
      measurement of this marker in saliva may be more useful than in serum for 
      determining diagnostic and therapeutic aims.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Mozaffari, Hamid Reza
AU  - Mozaffari HR
AD  - Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran; Medical Biology Research 
      Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
FAU - Ramezani, Mazaher
AU  - Ramezani M
AD  - Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran.
FAU - Mahmoudiahmadabadi, Mohammad
AU  - Mahmoudiahmadabadi M
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Omidpanah, Neda
AU  - Omidpanah N
AD  - Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Sadeghi, Masoud
AU  - Sadeghi M
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran. Electronic address: Sadeghi_mbrc@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170623
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol
JT  - Oral surgery, oral medicine, oral pathology and oral radiology
JID - 101576782
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Disease Progression
MH  - Humans
MH  - Lichen Planus, Oral/*metabolism
MH  - Saliva/*chemistry
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2017/08/22 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/08/22 06:00
PHST- 2017/02/04 00:00 [received]
PHST- 2017/06/14 00:00 [revised]
PHST- 2017/06/17 00:00 [accepted]
PHST- 2017/08/22 06:00 [entrez]
PHST- 2017/08/22 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
AID - S2212-4403(17)30974-4 [pii]
AID - 10.1016/j.oooo.2017.06.117 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Sep;124(3):e183-e189. doi: 
      10.1016/j.oooo.2017.06.117. Epub 2017 Jun 23.