PMID- 2882537
OWN - NLM
STAT- MEDLINE
DCOM- 19870520
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 91
IP  - 3
DP  - 1987
TI  - Self-injection of d,1-3,4-methylenedioxymethamphetamine (MDMA) in the baboon.
PG  - 268-72
AB  - MDMA (d,1-3,4-Methylenedioxymethamphetamine HCl; "ecstasy") self-injection 
      (0.1-3.2 mg/kg/injection) was examined in baboons under conditions in which 
      baseline responding was maintained by intravenous injections of cocaine HCl (0.32 
      mg/kg/injection). Drug was available under a FR 160-response schedule of 
      intravenous injection. Each drug injection was followed by a 3-h time out 
      allowing a maximum of eight injections per day. MDMA or MDMA vehicle (saline) was 
      substituted for cocaine for a period of 14 or more days followed by a return to 
      the cocaine baseline. MDMA (0.32-3.2 mg/kg/inj) maintained more injections and 
      higher responses rates than were maintained by saline. The maximal number of 
      injections maintained by MDMA and the maximal response rate maintained by MDMA 
      were less than those maintained under baseline conditions with cocaine. The 
      highest dose of MDMA tested maintained a cyclic pattern of self-injection, i.e., 
      days of high numbers of injections intermixed with days of low numbers of 
      injections. At the highest dose of MDMA tested, concurrent food maintained 
      behavior was suppressed to an extent that food intake was also decreased.
FAU - Lamb, R J
AU  - Lamb RJ
FAU - Griffiths, R R
AU  - Griffiths RR
LA  - eng
GR  - DA-01147/DA/NIDA NIH HHS/United States
GR  - DA-05237/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*administration & dosage/analogs & 
      derivatives/pharmacology
MH  - Amphetamines/*administration & dosage
MH  - Animals
MH  - Cocaine/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Papio
MH  - *Self Administration
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1007/BF00518175 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1987;91(3):268-72. doi: 10.1007/BF00518175.