PMID- 2882676
OWN - NLM
STAT- MEDLINE
DCOM- 19870521
LR  - 20220408
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 82
IP  - 4
DP  - 1987 Apr
TI  - Hyperparathyroidism presenting as the first lesion in multiple endocrine 
      neoplasia type 1.
PG  - 731-7
AB  - In a study of 16 different families, 55 persons were considered to be affected by 
      the syndrome of multiple endocrine neoplasia type 1 (MEN-1). Serum calcium 
      measurements were available for all but six patients, long deceased, and 
      hypercalcemia was invariably present. All but four of these patients have been 
      subjected to surgery, and hyperparathyroidism was verified in each case. In all 
      the patients studied, hyperparathyroidism was apparently the first manifestation 
      of the MEN-1 syndrome. Pituitary tumors were detected in 23 patients, and there 
      was evidence of pancreatic lesions in 32. Although either the pituitary or 
      pancreatic manifestations dominated clinically in some patients, 
      hyperparathyroidism was invariably present when sought. Measurement of serum 
      calcium in asymptomatic relatives at risk for MEN-1 disclosed no case of 
      hyperparathyroidism in children below the age of 18, whereas half of all screened 
      persons between the ages of 18 and 30 were found to have hyperparathyroidism. In 
      some, the serum calcium values were only marginally or even intermittently 
      elevated. It is concluded that since hyperparathyroidism is apparently the first 
      lesion in MEN-1, screening for this syndrome should primarily be directed toward 
      the diagnosis of hyperparathyroidism. The temporal relationships suggest that 
      hyperparathyroidism could be a prerequisite for the other types of endocrine 
      neoplasms in the MEN-1 syndrome.
FAU - Benson, L
AU  - Benson L
FAU - Ljunghall, S
AU  - Ljunghall S
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Oberg, K
AU  - Oberg K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Calcium/blood
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism/blood/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/blood/*diagnosis/genetics
EDAT- 1987/04/01 00:00
MHDA- 1987/04/01 00:01
CRDT- 1987/04/01 00:00
PHST- 1987/04/01 00:00 [pubmed]
PHST- 1987/04/01 00:01 [medline]
PHST- 1987/04/01 00:00 [entrez]
AID - 0002-9343(87)90008-8 [pii]
AID - 10.1016/0002-9343(87)90008-8 [doi]
PST - ppublish
SO  - Am J Med. 1987 Apr;82(4):731-7. doi: 10.1016/0002-9343(87)90008-8.