PMID- 28827788
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20190315
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 21
TI  - Vitamin D supplementation improves serum markers associated with hepatic 
      fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, 
      placebo-controlled study.
PG  - 8905
LID - 10.1038/s41598-017-09512-7 [doi]
LID - 8905
AB  - Hepatic fibrosis is the net accumulation of matrix tissue components which 
      controlled by pro-fibrolytic enzymes, matrix metalloproteinases (MMPs), and 
      pro-fibrotic cytokine, TGF-beta(1), and enzymes, tissue inhibitors of MMPs (TIMPs). 
      Vitamin D (VD) supplementation has been shown to reverse these processes in vitro 
      and in vivo. This study sought to determine the effect of VD supplementation on 
      serum fibrotic markers in chronic hepatitis C (CHC) patients. Fifty-four CHC 
      patients with VD deficiency were randomized into two groups, a VD group (n = 29) 
      and a placebo group (n = 29). The serum levels of 25-hydroxy VD, TGF-beta(1), 
      TIMP-1, MMP2 and MMP9 were measured at baseline and at the end of the 6-week 
      study period. Upon correction of VD levels, TGF-beta(1) and TIMP-1 levels were 
      decreased, and the MMP2 and MMP9 levels were significantly increased in the VD 
      group. A comparison of the mean changes (delta) in the markers between groups 
      showed that TGF-beta(1) and TIMP-1 levels were significantly decreased and the MMP2 
      and MMP9 were significantly higher in the VD group than in the placebo group. By 
      using CHC patients as a model, this study provides additional evidence that VD 
      plays an important role in the reversal of hepatic fibrogenesis.
FAU - Komolmit, Piyawat
AU  - Komolmit P
AUID- ORCID: 0000-0002-1357-9547
AD  - Division of Gastroenterology, Department of Medicine, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand. pkomolmit@yahoo.co.uk.
AD  - Center of Excellence in Liver Diseases: King Chulalongkorn Memorial Hospital, 
      Thai Red Cross Society, Bangkok, Thailand. pkomolmit@yahoo.co.uk.
FAU - Kimtrakool, Sayamon
AU  - Kimtrakool S
AD  - Gastroenterology Unit, Department of Medicine, Lerdsin Hospital, Bangkok, 
      Thailand.
FAU - Suksawatamnuay, Sirinporn
AU  - Suksawatamnuay S
AD  - Division of Gastroenterology, Department of Medicine, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
AD  - Center of Excellence in Liver Diseases: King Chulalongkorn Memorial Hospital, 
      Thai Red Cross Society, Bangkok, Thailand.
FAU - Thanapirom, Kessarin
AU  - Thanapirom K
AD  - Division of Gastroenterology, Department of Medicine, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
AD  - Center of Excellence in Liver Diseases: King Chulalongkorn Memorial Hospital, 
      Thai Red Cross Society, Bangkok, Thailand.
FAU - Chattrasophon, Kanita
AU  - Chattrasophon K
AD  - Gastroenterology Unit, Department of Medicine, Taksin Hospital, Bangkok, 
      Thailand.
FAU - Thaimai, Panarat
AU  - Thaimai P
AD  - Division of Gastroenterology, Department of Medicine, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
FAU - Chirathaworn, Chintana
AU  - Chirathaworn C
AD  - Division of Immunology, Department of Microbiology, Faculty of Medicine, 
      Chulalongkorn University, Bangkok, Thailand.
FAU - Poovorawan, Yong
AU  - Poovorawan Y
AD  - Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn 
      University, Bangkok, Thailand.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170821
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - *Dietary Supplements
MH  - Female
MH  - Genotype
MH  - Hepacivirus/genetics
MH  - Hepatitis C, Chronic/*blood/*complications/virology
MH  - Humans
MH  - Liver Cirrhosis/*drug therapy/*etiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Transforming Growth Factor beta1/blood
MH  - Viral Load
MH  - Vitamin D/*administration & dosage/analogs & derivatives/blood
PMC - PMC5566364
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/23 06:00
MHDA- 2019/03/16 06:00
PMCR- 2017/08/21
CRDT- 2017/08/23 06:00
PHST- 2017/05/17 00:00 [received]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/08/23 06:00 [entrez]
PHST- 2017/08/23 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
PHST- 2017/08/21 00:00 [pmc-release]
AID - 10.1038/s41598-017-09512-7 [pii]
AID - 9512 [pii]
AID - 10.1038/s41598-017-09512-7 [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 21;7(1):8905. doi: 10.1038/s41598-017-09512-7.