PMID- 28828353
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2287-8882 (Print)
IS  - 2287-903X (Electronic)
IS  - 2287-8882 (Linking)
VI  - 5
IP  - 3
DP  - 2017 Sep
TI  - Impact of poor glycemic control of type 2 diabetes mellitus on serum 
      prostate-specific antigen concentrations in men.
PG  - 104-109
LID - 10.1016/j.prnil.2017.02.004 [doi]
AB  - BACKGROUND: To evaluate the impact of poor glycemic control of type 2 diabetes 
      mellitus (T2DM) on serum prostate-specific antigen (PSA) concentrations in men. 
      METHODS: We performed a prospective analysis of 215 consecutive patients affected 
      by erectile dysfunction (ED). ED was evaluated using the IIEF-5 questionnaire and 
      the poor glycemic control (PGC) of T2DM was assessed according to the HbA1c 
      criteria (International Diabetes Federation). Patients were divided into PGC 
      group (HbA1c >/= 7%) and control group (CG) (HbA1c < 6%). Correlations between 
      serum HbA1c levels and various variables were evaluated and multivariate logistic 
      regression analyses were carried out to identify variables for PGC. RESULTS: We 
      compared 110 cases to 105 controls men ranging from 44 to 81 years of age, lower 
      PSA concentrations were observed in men with PGC (PGC mean PSA: 0.9 ng/dl, CG 
      mean PSA: 2.1 ng/dl, p < 0.001). Also mean prostate volume was 60% was smaller 
      among men with PGC compared with men with CG (PGC mean prostate volume: 26 ml, CG 
      prostate volume: 43 ml, p < 0.001). A strong negative correlation was found 
      between serum HbA1c levels and serum PSA (p < 0.001 and r = -0.665) 
      concentrations in men with PGC. We also found at the multivariate logistic 
      regression model that PSA, prostate volume and peak systolic velocity were 
      independent predictors of PGC. CONCLUSION: Our results suggest that there is 
      significant impact of PGC on serum PSA levels in T2DM. Poor glycemic control of 
      type 2 diabetes was associated with lower serum PSA levels and smaller prostate 
      volumes.
FAU - Atalay, Hasan Anil
AU  - Atalay HA
AD  - Department of Urology, Okmeydani Training and Research Hospital, Sisli, Istanbul, 
      Turkey.
FAU - Akarsu, Murat
AU  - Akarsu M
AD  - Department of Internal Medicine, Okmeydani Training and Research Hospital, Sisli, 
      Istanbul, Turkey.
FAU - Canat, Lutfi
AU  - Canat L
AD  - Department of Urology, Okmeydani Training and Research Hospital, Sisli, Istanbul, 
      Turkey.
FAU - Ulker, Volkan
AU  - Ulker V
AD  - Department of Urology, Izmir Tepecik Training and Research Hospital, Izmir, 
      Turkey.
FAU - Alkan, Ilter
AU  - Alkan I
AD  - Department of Urology, Okmeydani Training and Research Hospital, Sisli, Istanbul, 
      Turkey.
FAU - Ozkuvanci, Unsal
AU  - Ozkuvanci U
AD  - Department of Urology, Istanbul University Medical School, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - Korea (South)
TA  - Prostate Int
JT  - Prostate international
JID - 101605566
PMC - PMC5551940
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - HbA1c
OT  - PSA
EDAT- 2017/08/23 06:00
MHDA- 2017/08/23 06:01
PMCR- 2017/03/03
CRDT- 2017/08/23 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2017/02/06 00:00 [revised]
PHST- 2017/02/19 00:00 [accepted]
PHST- 2017/08/23 06:00 [entrez]
PHST- 2017/08/23 06:00 [pubmed]
PHST- 2017/08/23 06:01 [medline]
PHST- 2017/03/03 00:00 [pmc-release]
AID - S2287-8882(16)30069-1 [pii]
AID - 10.1016/j.prnil.2017.02.004 [doi]
PST - ppublish
SO  - Prostate Int. 2017 Sep;5(3):104-109. doi: 10.1016/j.prnil.2017.02.004. Epub 2017 
      Mar 3.