PMID- 28828713
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20181113
IS  - 1573-742X (Electronic)
IS  - 0929-5305 (Linking)
VI  - 44
IP  - 3
DP  - 2017 Oct
TI  - Efficacy of standard dose unfractionated heparin for venous thromboembolism 
      prophylaxis in morbidly obese and non-morbidly obese critically Ill patients.
PG  - 386-391
LID - 10.1007/s11239-017-1535-8 [doi]
AB  - To determine the efficacy of standard dose unfractionated heparin (UFH) for 
      venous thromboembolism (VTE) prophylaxis in critically ill morbidly obese 
      patients. Retrospective single-center observational cohort study in a single 
      tertiary teaching hospital intensive care units (ICUs) in Multiparameter 
      Intelligent Monitoring in Intensive Care II Clinical Database. Patients 18 years 
      or older, admitted to the ICU, and received either UFH 5000 units subcutaneously 
      twice daily or UFH 5000 units three times daily for VTE prophylaxis between 2001 
      and 2008 were included. Total 243 patients in the BMI >/= 40 kg/m(2) group and 2813 
      patients in the BMI < 40 kg/m(2) group were identified. There was no difference 
      in VTE incidence between the two groups. However, a strong linear association was 
      found showing as BMI increased so did the rate of VTE incidence. Morbidly obese 
      patients had longer hospital (17 vs. 14 days, P = 0.016) and ICU length of stay 
      (10 vs. 8 days, P = 0.007). After controlling Padua score, logistic regression 
      analysis revealed the odds of VTE increased by a factor of 1.026 for each 
      one-unit increase in BMI. Additionally, having a BMI >/= 40 kg/m(2) was associated 
      with a greater likelihood of VTE incidence in males (OR 3.92) but not in females. 
      In patients treated with standard dose UFH, morbid obesity does not increase VTE 
      risk overall. However, BMI has a strong linear relationship with VTE incidence 
      and morbid obesity is more likely associated with greater hospital and ICU length 
      of stay.
FAU - Lee, Young R
AU  - Lee YR
AUID- ORCID: 0000-0002-7677-2125
AD  - Department of Pharmacy Practice, Adult Medicine Division, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1718 Pine Street, Abilene, TX, 
      79601, USA. young.lee@ttuhsc.edu.
FAU - Blanco, Delilah D
AU  - Blanco DD
AD  - School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Critical Illness
MH  - Female
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Intensive Care Units
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*complications
MH  - Premedication
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Venous Thromboembolism/*prevention & control
OTO - NOTNLM
OT  - Critically ill
OT  - Heparin
OT  - Morbidly obese
OT  - Venous thromboembolism prophylaxis
EDAT- 2017/08/23 06:00
MHDA- 2018/08/02 06:00
CRDT- 2017/08/23 06:00
PHST- 2017/08/23 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2017/08/23 06:00 [entrez]
AID - 10.1007/s11239-017-1535-8 [pii]
AID - 10.1007/s11239-017-1535-8 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2017 Oct;44(3):386-391. doi: 10.1007/s11239-017-1535-8.