PMID- 28828881
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20180905
IS  - 2048-8734 (Electronic)
IS  - 2048-8726 (Linking)
VI  - 7
IP  - 4
DP  - 2018 Jun
TI  - Correlates and prognostic impact of new-onset heart failure after ST-segment 
      elevation myocardial infarction treated with primary percutaneous coronary 
      intervention: insights from the INFUSE-AMI trial.
PG  - 339-347
LID - 10.1177/2048872617719649 [doi]
AB  - BACKGROUND: The determinants and significance of early (30-day) heart failure 
      symptoms after primary percutaneous coronary intervention for ST-segment 
      elevation myocardial infarction (STEMI) remain unclear. We investigated the 
      clinical and imaging correlates of early post-discharge heart failure in patients 
      with STEMI, and evaluated its impact on clinical outcomes. METHODS: Patients from 
      the INFUSE-AMI trial were categorized according to New York Heart Association 
      (NYHA) functional classification at their 30-day visit (NYHA class >/=2 versus 1). 
      Independent correlates of NYHA class >/=2 were determined by multivariable logistic 
      regression. A landmark analysis beyond 30 days was performed to assess the impact 
      of 30-day NYHA class >/=2 on 1-year risk of death or hospitalization for heart 
      failure. RESULTS: Among 402 patients enrolled in the INFUSE-AMI trial with data 
      on NYHA class at 30 days, 76 (18.9%) had NYHA class >/=2. Independent correlates of 
      30-day NYHA class >/=2 were age, Killip class >/=2 at presentation, heart rate at 
      presentation, intraprocedural no-reflow, and 30-day infarct size (% total 
      ventricular mass). After adjustment for infarct size, patients with NYHA class >/=2 
      remained at higher risk of death or hospitalization for heart failure at 1-year 
      follow-up compared to those in NYHA class 1 (11.8% vs. 2.8%, adjusted hazard 
      ratio 3.78, 95% confidence interval 1.16-12.22, P=0.03). CONCLUSIONS: Clinical, 
      procedural, and imaging variables predict the development of clinical heart 
      failure after primary percutaneous coronary intervention in patients with STEMI. 
      Early post-discharge heart failure symptoms identify a high-risk patient cohort 
      for subsequent heart failure hospitalization and death, independent of infarct 
      size. TRIAL REGISTRATION: ClinicalTrials.gov ; NCT00976521.
FAU - Giustino, Gennaro
AU  - Giustino G
AD  - 1 Zena and Michael A Wiener Cardiovascular Institute, The Icahn School of 
      Medicine at Mount Sinai, USA.
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
FAU - Redfors, Bjorn
AU  - Redfors B
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
FAU - Brener, Sorin J
AU  - Brener SJ
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
AD  - 3 Department of Medicine, New York Methodist Hospital, USA.
FAU - Kirtane, Ajay J
AU  - Kirtane AJ
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
AD  - 4 Department of Cardiology, NewYork-Presbyterian Hospital/Columbia University 
      Medical Center, USA.
FAU - Genereux, Philippe
AU  - Genereux P
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
AD  - 5 Department of Medicine, Hopital du Sacre-Coeur de Montreal, Canada.
FAU - Maehara, Akiko
AU  - Maehara A
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
AD  - 4 Department of Cardiology, NewYork-Presbyterian Hospital/Columbia University 
      Medical Center, USA.
FAU - Dudek, Dariusz
AU  - Dudek D
AD  - 6 Department of Medicine, Department of Interventional Cardiology, Jagiellonian 
      University Medical College, Poland.
FAU - Neunteufl, Thomas
AU  - Neunteufl T
AD  - 7 Department of Medicine, Universitatsklinikum Krems, Austria.
FAU - Metzger, D Christopher
AU  - Metzger DC
AD  - 8 Wellmont CVA Heart Institute, USA.
FAU - Crowley, Aaron
AU  - Crowley A
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
FAU - Mehran, Roxana
AU  - Mehran R
AD  - 1 Zena and Michael A Wiener Cardiovascular Institute, The Icahn School of 
      Medicine at Mount Sinai, USA.
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
FAU - Gibson, C Michael
AU  - Gibson CM
AD  - 9 Department of Cardiology, Beth Israel Deaconess Med Center, USA.
FAU - Stone, Gregg W
AU  - Stone GW
AD  - 2 Clinical Trials Center, Cardiovascular Research Foundation, USA.
AD  - 4 Department of Cardiology, NewYork-Presbyterian Hospital/Columbia University 
      Medical Center, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT00976521
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20170822
PL  - England
TA  - Eur Heart J Acute Cardiovasc Care
JT  - European heart journal. Acute cardiovascular care
JID - 101591369
SB  - IM
MH  - Aged
MH  - Austria/epidemiology
MH  - Cause of Death/trends
MH  - Coronary Angiography
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/epidemiology/*etiology
MH  - Humans
MH  - Incidence
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Poland/epidemiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Quebec/epidemiology
MH  - *Risk Assessment
MH  - ST Elevation Myocardial Infarction/diagnosis/mortality/*surgery
MH  - Single-Blind Method
MH  - Survival Rate/trends
MH  - Time Factors
MH  - United States/epidemiology
OTO - NOTNLM
OT  - New York Heart Association
OT  - ST-segment elevation myocardial infarction
OT  - heart failure
OT  - infarct size
OT  - magnetic resonance imaging
EDAT- 2017/08/23 06:00
MHDA- 2018/09/06 06:00
CRDT- 2017/08/23 06:00
PHST- 2017/08/23 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2017/08/23 06:00 [entrez]
AID - 10.1177/2048872617719649 [doi]
PST - ppublish
SO  - Eur Heart J Acute Cardiovasc Care. 2018 Jun;7(4):339-347. doi: 
      10.1177/2048872617719649. Epub 2017 Aug 22.