PMID- 28829495
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 21
IP  - 15
DP  - 2017 Aug
TI  - The expression and mechanism of BDNF and NGB in perihematomal tissue in rats with 
      intracerebral hemorrhage.
PG  - 3452-3458
LID - 13214 [pii]
AB  - OBJECTIVE: To analyze how changes in the levels of brain-derived neurotrophic 
      factor (BDNF) and neuroglobin (NGB) affect learning and memory in rats with 
      intracerebral hemorrhage. MATERIALS AND METHODS: Thirty male Sprague-Dawley rats 
      were randomly divided into the control group, sham operation group and model 
      group with 10 rats each. The rats in the control group were untreated, while 
      those in the sham operation group were treated with sterile saline instead of 
      type VII collagenase injection in the globus pallidus. The model of cerebral 
      hemorrhage was established according to the methods described by Rosenberg. The 
      expression of perihematomal BDNF mRNA was measured by Real-time quantitative PCR 
      (RT-PCR) for 7 days consecutively. Perihematomal NGB-positive cells were detected 
      by immunohistochemistry. The Morris water maze was used to test the spatial 
      learning and memory of rats. RESULTS: Compared with the control group and sham 
      operation group, the expression of BDNF mRNA and number of NGB-positive cells in 
      the model group were significantly higher. Furthermore, the escape latency was 
      significantly prolonged (p < 0.05). The NGB and BDNF mRNA levels and escape 
      latency were positively correlated. The correlation coefficients were as follows: 
      rs (NGB) = 1.1838 (p = 0.008); rs (BDNF) = 0.5948 (p = 0.012). CONCLUSIONS: 
      Cerebral hemorrhage significantly inhibited the spatial learning and memory 
      ability of rats. The mechanism may be related to decreased cerebral expression of 
      BDNF and NGB.
FAU - Guo, Y-C
AU  - Guo YC
AD  - Department of Neurosurgery, The Second People's Hospital of Liaocheng, Linqing 
      City, Shandong Province, China. lc-hpj @163.com.
FAU - Song, X-K
AU  - Song XK
FAU - Xu, Y-F
AU  - Xu YF
FAU - Ma, J-B
AU  - Ma JB
FAU - Zhang, J-J
AU  - Zhang JJ
FAU - Han, P-J
AU  - Han PJ
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroglobin)
RN  - 0 (RNA, Messenger)
RN  - 9004-22-2 (Globins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebral Hemorrhage/*genetics
MH  - Globins/*genetics
MH  - Learning
MH  - Male
MH  - Memory
MH  - Nerve Tissue Proteins/*genetics
MH  - Neuroglobin
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2017/08/23 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/08/23 06:00
PHST- 2017/08/23 06:00 [entrez]
PHST- 2017/08/23 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
AID - 13214 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3452-3458.