PMID- 2882955 OWN - NLM STAT- MEDLINE DCOM- 19870624 LR - 20211203 IS - 0301-0171 (Print) IS - 0301-0171 (Linking) VI - 44 IP - 2-3 DP - 1987 TI - Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. PG - 76-81 AB - Molecular probes were used as markers in the backcross (Czech II X BALB/cPt) X Czech II to determine the positions of six genes on mouse chromosome 16 (MMU 16). The order of the genes mapped is (centromere), protamine-1 (Prm-1), immunoglobulin lambda 1 light chain (Igl-1), preprosomatostatin (Smst), an endogenous mouse mammary tumor virus locus (Mtv-6), and two more distal sequences, superoxide dismutase, cytoplasmic form (Sod-1), and the proto-oncogene sequence Ets-2. The largest recombination frequency between any two adjacent markers is 24 cM, and thus the position of any marker on MMU 16 that is polymorphic between these two strains can be readily determined in this backcross. A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome. FAU - Reeves, R H AU - Reeves RH FAU - Gallahan, D AU - Gallahan D FAU - O'Hara, B F AU - O'Hara BF FAU - Callahan, R AU - Callahan R FAU - Gearhart, J D AU - Gearhart JD LA - eng GR - P01-19920/PHS HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Switzerland TA - Cytogenet Cell Genet JT - Cytogenetics and cell genetics JID - 0367735 RN - 0 (Genetic Markers) RN - 0 (MAS1 protein, human) RN - 0 (Proto-Oncogene Mas) RN - 9007-49-2 (DNA) SB - IM MH - Animals MH - *Chromosome Mapping MH - DNA/genetics MH - Down Syndrome/*genetics MH - Genetic Linkage MH - *Genetic Markers MH - Humans MH - Karyotyping MH - Mice MH - Mice, Inbred Strains MH - Polymorphism, Restriction Fragment Length MH - Proto-Oncogene Mas MH - Recombination, Genetic EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] AID - 10.1159/000132347 [doi] PST - ppublish SO - Cytogenet Cell Genet. 1987;44(2-3):76-81. doi: 10.1159/000132347.