PMID- 28830802
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 2589-0646 (Electronic)
IS  - 2589-0646 (Linking)
VI  - 11
IP  - 1
DP  - 2018 Mar
TI  - Impact of vitamin D deficiency on increased blood eosinophil counts.
PG  - 25-29
LID - S1658-3876(17)30093-6 [pii]
LID - 10.1016/j.hemonc.2017.06.003 [doi]
AB  - OBJECTIVE/BACKGROUND: Vitamin D has been increasingly recognized as an 
      immunomodulatory agent. Its deficiency has been associated with immune-mediated 
      diseases such as asthma, rhinitis, and atopic dermatitis. These allergic 
      conditions are dependent on T-helper type 2 (Th2) cells secreting interleukins, 
      overproduction of immunoglobulin E (IgE), and eosinophil activation. We 
      investigated the association between serum vitamin D levels and blood absolute 
      eosinophil count. METHODS: We carried out a cross-sectional study of 669 men and 
      women referred to a clinical pathology laboratory who underwent 25-hydroxyvitamin 
      D testing and complete blood count analysis on the same day. RESULTS: Vitamin D 
      levels were stratified into four ranges: severely deficient (<10ng/mL), deficient 
      (>/=10ng/mL and <20ng/mL), insufficient (>/=20ng/mL and <30ng/mL), or sufficient 
      (>/=30ng/mL). The mean/median eosinophil count in the four groups was 
      267/254cells/muL, 245/238cells/muL, 191/159cells/muL, and 182/146cells/muL, 
      respectively, (p=.001). The difference was significant between the severe 
      deficiency group and each of the other three groups (p=.012, p=.002, and p=.001, 
      respectively). There was no statistical difference among the four groups in terms 
      of total leukocyte counts (p=.151), neutrophils (p=.177), or lymphocytes 
      (p=.582). CONCLUSION: Vitamin D deficiency was associated with higher blood 
      eosinophil count. These results support the possible role of vitamin D in the 
      eosinophil immune response.
CI  - Copyright (c) 2017 King Faisal Specialist Hospital & Research Centre. Published by 
      Elsevier B.V. All rights reserved.
FAU - Souto Filho, Joao Tadeu Damian
AU  - Souto Filho JTD
AD  - Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil; 
      Instituto Federal de Educacao, Ciencia e Tecnologia Fluminense, Campos dos 
      Goytacazes, Rio de Janeiro, Brazil. Electronic address: drjoaotadeu@yahoo.com.br.
FAU - de Andrade, Alicia Souza
AU  - de Andrade AS
AD  - Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil.
FAU - Ribeiro, Felipe Mesquita
AU  - Ribeiro FM
AD  - Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil.
FAU - Alves, Paola de Araujo Sardenberg
AU  - Alves PAS
AD  - Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil.
FAU - Simonini, Virginia Ribeiro Fernandes
AU  - Simonini VRF
AD  - Faculdade de Medicina de Campos, Campos dos Goytacazes, Rio de Janeiro, Brazil.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170816
PL  - Saudi Arabia
TA  - Hematol Oncol Stem Cell Ther
JT  - Hematology/oncology and stem cell therapy
JID - 101468532
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoimmune Diseases/*blood/complications/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - *Eosinophils
MH  - Female
MH  - Humans
MH  - Infant
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Vitamin D/*analogs & derivatives/blood/immunology
MH  - Vitamin D Deficiency/*blood/complications/immunology
OTO - NOTNLM
OT  - Eosinophilia
OT  - Eosinophils
OT  - Vitamin D
OT  - Vitamin D deficiency
EDAT- 2017/08/24 06:00
MHDA- 2018/10/10 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/04/19 00:00 [received]
PHST- 2017/06/26 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - S1658-3876(17)30093-6 [pii]
AID - 10.1016/j.hemonc.2017.06.003 [doi]
PST - ppublish
SO  - Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):25-29. doi: 
      10.1016/j.hemonc.2017.06.003. Epub 2017 Aug 16.