PMID- 28831093 OWN - NLM STAT- MEDLINE DCOM- 20190321 LR - 20220318 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 7 IP - 1 DP - 2017 Aug 22 TI - Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study. PG - 9072 LID - 10.1038/s41598-017-09136-x [doi] LID - 9072 AB - Limited information is available on the effect of hypertriglyceridemia-waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Cox regression yielded hazard ratios relating HTGW (based on TG level and WC at baseline and follow-up) to risk of developing T2DM. After a median follow-up of 6.0 years (71,432 person-years of follow-up), T2DM developed in 621 participants. For HTGW participants, the incidence of T2DM was 26.4/1000, 20.6/1000, and 21.9/1000 person-years for males, females, and overall, respectively. The adjusted HR for HTGW associated with T2DM was 7.63 (95% CI 4.32-13.49) for males and 7.75 (4.71-12.78) for females. Compared with consistent HTGW, with transformation from baseline HTGW to normal WC and normal triglycerides level at follow-up, the risk of developing T2DM was reduced by 75% and 78% for males and females. HTGW is a major risk factor for T2DM, but the risk could be reduced by improved triglycerides level and WC. FAU - Ren, Yongcheng AU - Ren Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Liu, Yu AU - Liu Y AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Sun, Xizhuo AU - Sun X AD - The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Deng, Kunpeng AU - Deng K AD - Yantian Entry-exit Inspection and Quarantine Bureau, Shenzhen, Guangdong, People's Republic of China. FAU - Wang, Chongjian AU - Wang C AUID- ORCID: 0000-0001-5091-6621 AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Li, Linlin AU - Li L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Lu AU - Zhang L AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Wang, Bingyuan AU - Wang B AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhou, Junmei AU - Zhou J AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Han, Chengyi AU - Han C AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Hongyan AU - Zhang H AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Yang, Xiangyu AU - Yang X AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. FAU - Luo, Xinping AU - Luo X AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Pang, Chao AU - Pang C AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Yin, Lei AU - Yin L AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Feng, Tianping AU - Feng T AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Zhao, Jingzhi AU - Zhao J AD - Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, People's Republic of China. FAU - Zhang, Ming AU - Zhang M AD - Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China. FAU - Hu, Dongsheng AU - Hu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China. hud@szu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170822 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adult MH - China/epidemiology MH - Cohort Studies MH - Diabetes Mellitus, Type 2/*epidemiology/*etiology MH - Female MH - Humans MH - Hypertriglyceridemia/*complications MH - Incidence MH - Insulin Resistance MH - Insulin-Secreting Cells/metabolism MH - Male MH - Middle Aged MH - Phenotype MH - Risk Assessment MH - Risk Factors MH - Rural Population MH - *Waist Circumference PMC - PMC5567308 COIS- The authors declare that they have no competing interests. EDAT- 2017/08/24 06:00 MHDA- 2019/03/22 06:00 PMCR- 2017/08/22 CRDT- 2017/08/24 06:00 PHST- 2016/07/27 00:00 [received] PHST- 2017/07/20 00:00 [accepted] PHST- 2017/08/24 06:00 [entrez] PHST- 2017/08/24 06:00 [pubmed] PHST- 2019/03/22 06:00 [medline] PHST- 2017/08/22 00:00 [pmc-release] AID - 10.1038/s41598-017-09136-x [pii] AID - 9136 [pii] AID - 10.1038/s41598-017-09136-x [doi] PST - epublish SO - Sci Rep. 2017 Aug 22;7(1):9072. doi: 10.1038/s41598-017-09136-x.