PMID- 28831671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220801
IS  - 1523-3847 (Print)
IS  - 1523-3847 (Linking)
VI  - 19
IP  - 10
DP  - 2017 Aug 22
TI  - Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, 
      Coccidiodomycosis, and Talaromycosis.
PG  - 36
LID - 10.1007/s11908-017-0592-7 [doi]
AB  - PURPOSE OF REVIEW: The goal of this review is to provide an update on the 
      epidemiology, diagnosis, and treatment of opportunistic fungal infections in 
      patients with human immunodeficiency virus (HIV) infection including Cryptococcus 
      spp., Histoplasma spp., Coccidioides spp., and Talaromyces marneffei, formerly 
      Penicillium marneffei. RECENT FINDINGS: In many settings, despite increasing roll 
      out of antiretroviral therapy (ART), opportunistic invasive mycoses produce a 
      substantial burden of disease. The prevalence of specific fungal pathogens 
      depends on their endemicity. Viral suppression achieved by greater access to ART 
      and increased the availability of point-of-care testing with rapid diagnostic 
      tests (RDTs) aid to curtail the associated fungi morbidity. RDTs allow earlier 
      screening to preemptively initiate treatment of opportunistic fungal pathogens. 
      Identifying asymptomatic cryptococcal infection before starting ART is crucial in 
      reducing the risk of the immune reconstitution inflammatory syndrome (IRIS). 
      There is an urgent need to decrease the burden of opportunistic invasive fungal 
      infections in individuals with HIV/AIDS through different interventions: (a) 
      continue to expand the deployment of ART to the most affected populations to 
      achieve viral suppression; (b) ensure early diagnosis of fungal pathogen with 
      point-of-care testing;
CI  - (c) improve fungal diagnostic capacity in areas with the highest burden of 
      AIDS-related mycoses; and (d) increased availability of existing antifungal drugs 
      to optimally treat these infections.
FAU - Chastain, Daniel B
AU  - Chastain DB
AD  - University of Georgia College of Pharmacy, 1000 Jefferson Street, Albany, GA, 
      31701, USA. daniel.chastain@uga.edu.
FAU - Henao-Martinez, Andres F
AU  - Henao-Martinez AF
AD  - University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA.
FAU - Franco-Paredes, Carlos
AU  - Franco-Paredes C
AD  - University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA.
AD  - Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170822
PL  - United States
TA  - Curr Infect Dis Rep
JT  - Current infectious disease reports
JID - 100888983
OTO - NOTNLM
OT  - AIDS-related mycoses
OT  - Coccidioidomycosis
OT  - Cryptococcosis
OT  - HIV/AIDS
OT  - Histoplasmosis
OT  - Penicilliosis
OT  - Talaromycosis
EDAT- 2017/08/24 06:00
MHDA- 2017/08/24 06:01
CRDT- 2017/08/24 06:00
PHST- 2017/08/24 06:00 [entrez]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2017/08/24 06:01 [medline]
AID - 10.1007/s11908-017-0592-7 [pii]
AID - 10.1007/s11908-017-0592-7 [doi]
PST - epublish
SO  - Curr Infect Dis Rep. 2017 Aug 22;19(10):36. doi: 10.1007/s11908-017-0592-7.