PMID- 2883195
OWN - NLM
STAT- MEDLINE
DCOM- 19870623
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 64
IP  - 6
DP  - 1987 Jun
TI  - A standardized meal stimulation test of the endocrine pancreas for early 
      detection of pancreatic endocrine tumors in multiple endocrine neoplasia type 1 
      syndrome: five years experience.
PG  - 1233-40
AB  - Forty-nine members of 6 families with multiple endocrine neoplasia type 1 (MEN 1) 
      were investigated with a standardized meal stimulation test to detect the 
      presence of pancreatic endocrine tumors. Fifteen age-matched subjects and 4 
      patients with primary hyperparathyroidism also were studied. Serum pancreatic 
      polypeptide (PP), gastrin, and insulin as well as plasma glucagon and 
      somatostatin concentrations were determined before and during the test meal. 
      Patients with demonstrable pancreatic endocrine tumors had significantly 
      increased mean basal and peak serum PP (P less than 0.001) and gastrin (P less 
      than 0.001) responses to the meal compared with healthy family members and normal 
      subjects. Seven of 12 MEN 1 patients with parathyroid and pituitary disease but 
      no demonstrable pancreatic endocrine tumors had exaggerated PP and/or gastrin 
      responses to the meal; 4 of them developed pancreatic endocrine tumors, detected 
      by abdominal computerized tomography, 0.5-4 yr later. None of the healthy members 
      of the MEN 1 families or the patients with primary hyperparathyroidism had 
      responses different from those of the normal subjects. Our experience with the 
      meal stimulation test indicates that an elevated basal or exaggerated serum PP 
      and/or gastrin response is an earlier sign of pancreatic involvement in the MEN 1 
      trait than is abdominal computerized tomography.
FAU - Skogseid, B
AU  - Skogseid B
FAU - Oberg, K
AU  - Oberg K
FAU - Benson, L
AU  - Benson L
FAU - Lindgren, P G
AU  - Lindgren PG
FAU - Lorelius, L E
AU  - Lorelius LE
FAU - Lundquist, G
AU  - Lundquist G
FAU - Wide, L
AU  - Wide L
FAU - Wilander, E
AU  - Wilander E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Pancreatic Hormones)
SB  - IM
MH  - Adenoma, Islet Cell/blood/complications/*diagnosis/physiopathology
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - *Food
MH  - Gastrointestinal Hormones/blood
MH  - Humans
MH  - Islets of Langerhans/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/blood/complications/*diagnosis/physiopathology
MH  - Pancreatic Hormones/blood
MH  - Retrospective Studies
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 10.1210/jcem-64-6-1233 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1987 Jun;64(6):1233-40. doi: 10.1210/jcem-64-6-1233.