PMID- 28832804
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20230201
IS  - 1806-9460 (Electronic)
IS  - 1516-3180 (Print)
IS  - 1516-3180 (Linking)
VI  - 136
IP  - 4
DP  - 2018 Jul-Aug
TI  - Complex karyotype including ring chromosome 11 in a patient with acute myeloid 
      leukemia: case report.
PG  - 361-367
LID - 10.1590/1516-3180.2016.0252150217 [doi]
AB  - CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by 
      an overall low response rate with frequent relapses after clinical treatment. 
      CASE REPORT: Here, we describe the case of a 61-year-old obese female with 
      clinically diagnosed AML who presented a complex karyotype involving an uncommon 
      abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the 
      diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and 
      FISH (fluorescence in situ hybridization), revealed the presence of complex 
      structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). 
      CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification 
      and characterization of chromosomal rearrangements in AML. Case reports like 
      this, as well as population-based studies, are necessary for understanding the 
      karyotypic changes that occur in humans.
FAU - Ornellas, Maria Helena Faria
AU  - Ornellas MHF
AD  - Associate Professor, Pathology Service, Universidade do Estado do Rio de Janeiro 
      (UERJ), Rio de Janeiro (RJ), Brazil.
FAU - Maioli, Maria Christina Paixao
AU  - Maioli MCP
AD  - Adjunct Professor, Hematology Service Universidade do Estado do Rio de Janeiro 
      (UERJ), Rio de Janeiro (RJ), Brazil.
FAU - Lucena, Stella Beatriz Sampaio Goncalves de
AU  - Lucena SBSG
AD  - Associate Professor, Hematology Service, Universidade do Estado do Rio de Janeiro 
      (UERJ), and Postdoctoral Research, Research Coordination, Instituto Nacional de 
      Cancer (INCA), Rio de Janeiro (RJ), Brazil.
FAU - Bastos, Elenice Ferreira
AU  - Bastos EF
AD  - Biologist, Hematology Department, Universidade do Estado do Rio de Janeiro 
      (UERJ), and Supervisor, Medical Genetics Department, Instituto Fernandes Figueira 
      (IFF), Rio de Janeiro (RJ), Brazil.
FAU - Chaves, Tatiana Silva
AU  - Chaves TS
AD  - Biologist, Hematology Service, Universidade do Estado do Rio de Janeiro (UERJ), 
      Rio de Janeiro (RJ), Brazil.
FAU - Melo, Karina Vieira de
AU  - Melo KV
AD  - Medical Sciences Master's Student, Hematology Service, Universidade do Estado do 
      Rio de Janeiro (UERJ), Rio de Janeiro (RJ), Brazil.
FAU - Ribeiro-Carvalho, Marilza de Moura
AU  - Ribeiro-Carvalho MM
AD  - Biologist and Postdoctoral Researcher, Pathology Department, Universidade do 
      Estado do Rio de Janeiro (UERJ), Rio de Janeiro (RJ), Brazil.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Biologist and Head of Molecular Cytogenetics Laboratory, Jena University 
      Hospital, Friedrich Schiller University, Institute of Human Genetics, Thuringen, 
      Germany.
FAU - Alves, Gilda
AU  - Alves G
AD  - Biologist and Professor, Universidade do Estado do Rio de Janeiro (UERJ), and 
      Researcher, Research Coordination, Instituto Nacional de Cancer (INCA), Rio de 
      Janeiro (RJ), Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170821
PL  - Brazil
TA  - Sao Paulo Med J
JT  - Sao Paulo medical journal = Revista paulista de medicina
JID - 100897261
SB  - IM
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotype
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Middle Aged
MH  - *Ring Chromosomes
MH  - Translocation, Genetic
PMC - PMC9881703
COIS- Conflict of interest: None
EDAT- 2017/08/24 06:00
MHDA- 2018/12/12 06:00
PMCR- 2017/08/21
CRDT- 2017/08/24 06:00
PHST- 2017/01/19 00:00 [received]
PHST- 2017/02/15 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
PHST- 2017/08/21 00:00 [pmc-release]
AID - S1516-31802017005010101 [pii]
AID - 10.1590/1516-3180.2016.0252150217 [doi]
PST - ppublish
SO  - Sao Paulo Med J. 2018 Jul-Aug;136(4):361-367. doi: 
      10.1590/1516-3180.2016.0252150217. Epub 2017 Aug 21.