PMID- 28833729 OWN - NLM STAT- MEDLINE DCOM- 20180516 LR - 20200225 IS - 1365-313X (Electronic) IS - 0960-7412 (Print) IS - 0960-7412 (Linking) VI - 92 IP - 3 DP - 2017 Nov TI - A CRY-BIC negative-feedback circuitry regulating blue light sensitivity of Arabidopsis. PG - 426-436 LID - 10.1111/tpj.13664 [doi] AB - Cryptochromes are blue light receptors that regulate various light responses in plants. Arabidopsis cryptochrome 1 (CRY1) and cryptochrome 2 (CRY2) mediate blue light inhibition of hypocotyl elongation and long-day (LD) promotion of floral initiation. It has been reported recently that two negative regulators of Arabidopsis cryptochromes, Blue light Inhibitors of Cryptochromes 1 and 2 (BIC1 and BIC2), inhibit cryptochrome function by blocking blue light-dependent cryptochrome dimerization. However, it remained unclear how cryptochromes regulate the BIC gene activity. Here we show that cryptochromes mediate light activation of transcription of the BIC genes, by suppressing the activity of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), resulting in activation of the transcription activator ELONGATED HYPOCOTYL 5 (HY5) that is associated with chromatins of the BIC promoters. These results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity of each other. Surprisingly, phytochromes also mediate light activation of BIC transcription, suggesting a novel photoreceptor co-action mechanism to sustain blue light sensitivity of plants under the broad spectra of solar radiation in nature. CI - (c) 2017 The Authors The Plant Journal (c) 2017 John Wiley & Sons Ltd. FAU - Wang, Xu AU - Wang X AUID- ORCID: 0000-0003-2210-6204 AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. AD - Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, 90095, USA. FAU - Wang, Qin AU - Wang Q AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. AD - Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, 90095, USA. FAU - Han, Yun-Jeong AU - Han YJ AD - Department of Biotechnology and Kumho Life Science Laboratory, Chonnam National University, Gwangju, 61186, Republic of Korea. FAU - Liu, Qing AU - Liu Q AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Gu, Lianfeng AU - Gu L AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Yang, Zhaohe AU - Yang Z AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Su, Jun AU - Su J AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Liu, Bobin AU - Liu B AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Zuo, Zecheng AU - Zuo Z AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - He, Wenjin AU - He W AD - Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, 90095, USA. AD - College of Life Sciences, Fujian Normal University, Fuzhou, 350108, China. FAU - Wang, Jian AU - Wang J AD - Institute of Crop Sciences, Ningxia Academy of Agriculture and Forestry Sciences, Ningxia, 750105, China. FAU - Liu, Bin AU - Liu B AD - Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. FAU - Matsui, Minami AU - Matsui M AD - Biomass Engineering Research Division, RIKEN Center for Sustainable Resource Science, Kanagawa, 230-0045, Japan. FAU - Kim, Jeong-Il AU - Kim JI AD - Department of Biotechnology and Kumho Life Science Laboratory, Chonnam National University, Gwangju, 61186, Republic of Korea. FAU - Oka, Yoshito AU - Oka Y AD - Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. FAU - Lin, Chentao AU - Lin C AD - Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, 90095, USA. LA - eng GR - R01 GM056265/GM/NIGMS NIH HHS/United States GR - R29 GM056265/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20171009 PL - England TA - Plant J JT - The Plant journal : for cell and molecular biology JID - 9207397 RN - 0 (Arabidopsis Proteins) RN - 0 (Basic-Leucine Zipper Transcription Factors) RN - 0 (CRY1 protein, Arabidopsis) RN - 0 (CRY2 protein, Arabidopsis) RN - 0 (Cryptochromes) RN - 0 (HY5 protein, Arabidopsis) RN - 0 (Nuclear Proteins) RN - 0 (Photoreceptors, Plant) RN - 11121-56-5 (Phytochrome) RN - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis) RN - EC 2.3.2.27 (Ubiquitin-Protein Ligases) SB - IM MH - Arabidopsis/*genetics/physiology/radiation effects MH - Arabidopsis Proteins/genetics/*metabolism MH - Basic-Leucine Zipper Transcription Factors/genetics/metabolism MH - Cryptochromes/genetics/*metabolism MH - Feedback, Physiological/*radiation effects MH - Gene Expression Regulation, Plant/genetics/radiation effects MH - Genes, Reporter MH - Light MH - Models, Biological MH - Nuclear Proteins/genetics/metabolism MH - Photoreceptors, Plant/genetics/*metabolism MH - Phytochrome/metabolism/radiation effects MH - Seedlings/genetics/physiology/radiation effects MH - Ubiquitin-Protein Ligases/genetics/metabolism PMC - PMC6717659 MID - NIHMS1013274 OTO - NOTNLM OT - Arabidopsis thaliana OT - blue light inhibitors of cryptochromes (BIC) OT - cryptochrome (CRY) OT - negative-feedback circuitry COIS- CONFLICT OF INTEREST The authors declare no conflict of interest. EDAT- 2017/08/24 06:00 MHDA- 2018/05/17 06:00 PMCR- 2019/09/01 CRDT- 2017/08/24 06:00 PHST- 2017/02/22 00:00 [received] PHST- 2017/08/04 00:00 [revised] PHST- 2017/08/08 00:00 [accepted] PHST- 2017/08/24 06:00 [pubmed] PHST- 2018/05/17 06:00 [medline] PHST- 2017/08/24 06:00 [entrez] PHST- 2019/09/01 00:00 [pmc-release] AID - 10.1111/tpj.13664 [doi] PST - ppublish SO - Plant J. 2017 Nov;92(3):426-436. doi: 10.1111/tpj.13664. Epub 2017 Oct 9.