PMID- 28833868
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20190912
IS  - 1552-6569 (Electronic)
IS  - 1051-2284 (Print)
IS  - 1051-2284 (Linking)
VI  - 28
IP  - 2
DP  - 2018 Mar
TI  - The Use of Visual Rating Scales to Quantify Brain MRI Lesions in Patients with 
      HIV Infection.
PG  - 217-224
LID - 10.1111/jon.12466 [doi]
AB  - BACKGROUND AND PURPOSE: Human immunodeficiency virus (HIV)-infected patients 
      commonly have abnormalities in cerebral white matter that are visible on magnetic 
      resonance imaging (MRI) as hyperintensities (WMHs). Visual rating scales (VRSs) 
      have been used to quantify WMH in other diseases such as cerebral small vessel 
      disease (CSVD), but not in HIV. Such scales are advantageous because they are 
      applicable to routinely acquired MRIs and so are suitable for large-scale studies 
      and clinical care. We sought to establish the utility of three VRSs (the Fazekas, 
      Scheltens, and van Sweiten scales) in HIV. METHODS: The Manhattan HIV Brain Bank 
      (MHBB) is a longitudinal cohort study that performs serial neurologic 
      examinations and neuropsychological testing. All brain MRIs (n = 73) performed 
      for clinical purposes on MHBB participants were scored using the three VRSs. We 
      assessed reliability, validity, and correlation of the VRS with clinical factors 
      relevant to HIV and CSVD. RESULTS: The VRSs all showed acceptable internal 
      consistency and interrater reliability and were highly correlated with one 
      another (r = 0.836-0.916, P < .001). The Fazekas and Scheltens scales 
      demonstrated more WMH in periventricular regions, and the Scheltens scale also 
      suggested a frontal to occipital gradient, with greater WMH frontally. All three 
      VRSs correlated significantly with cognitive impairment (global T score). Age and 
      hepatitis C virus antibody serostatus were the strongest clinical/demographic 
      correlates of WMH, followed by African-American race. CONCLUSIONS: VRSs reliably 
      quantify WMH in HIV-infected individuals and correlate with cognitive impairment. 
      Future studies may find routinely acquired brain MRI quantified by VRS to be an 
      accessible and meaningful neurologic outcome measure in HIV.
CI  - Copyright (c) 2017 by the American Society of Neuroimaging.
FAU - Robinson-Papp, Jessica
AU  - Robinson-Papp J
AD  - Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
FAU - Navis, Allison
AU  - Navis A
AD  - Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
FAU - Dhamoon, Mandip S
AU  - Dhamoon MS
AD  - Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
FAU - Clark, Uraina S
AU  - Clark US
AD  - Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
FAU - Gutierrez-Contreras, Jose
AU  - Gutierrez-Contreras J
AD  - Department of Neurology, Columbia University Medical Center, New York, NY.
FAU - Morgello, Susan
AU  - Morgello S
AD  - Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
LA  - eng
GR  - K23 MH096628/MH/NIMH NIH HHS/United States
GR  - R24 MH059724/MH/NIMH NIH HHS/United States
GR  - U24 MH100931/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170821
PL  - United States
TA  - J Neuroimaging
JT  - Journal of neuroimaging : official journal of the American Society of 
      Neuroimaging
JID - 9102705
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging/pathology
MH  - Female
MH  - HIV Infections/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Reproducibility of Results
MH  - White Matter/*diagnostic imaging/pathology
PMC - PMC5821603
MID - NIHMS896404
OTO - NOTNLM
OT  - HIV
OT  - MRI
OT  - cerebral small vessel disease
OT  - neurocognitive impairment
OT  - white matter hyperintensities
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2017/08/24 06:00
MHDA- 2019/09/13 06:00
PMCR- 2019/03/01
CRDT- 2017/08/24 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.1111/jon.12466 [doi]
PST - ppublish
SO  - J Neuroimaging. 2018 Mar;28(2):217-224. doi: 10.1111/jon.12466. Epub 2017 Aug 21.