PMID- 28834219
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20180625
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 44
IP  - 6
DP  - 2017 Dec
TI  - Human leucocyte antigens class II allele and haplotype association with Type 1 
      Diabetes in Madeira Island (Portugal).
PG  - 305-313
LID - 10.1111/iji.12335 [doi]
AB  - This study confirms for Madeira Island (Portugal) population the Type 1 Diabetes 
      (T1D) susceptible and protective Human leucocyte antigens (HLA) markers 
      previously reported in other populations and adds some local specificities. Among 
      the strongest T1D HLA associations, stands out, as susceptible, the alleles 
      DRB1*04:05 (OR = 7.3), DQB1*03:02 (OR = 6.1) and DQA1*03:03 (OR = 4.5), as well 
      as the haplotypes DRB1*04:05-DQA1*03:03-DQB1*03:02 (OR = 100.9) and 
      DRB1*04:04-DQA1*03:01-DQB1*03:02 (OR = 22.1), and DQB1*06:02 (OR = 0.07) and 
      DRB1*15:01-DQA1*01:02-DQB1*06:02 (OR = 0.04) as protective. HLA-DQA1 positive for 
      Arginine at position 52 (Arg52) (OR = 15.2) and HLA-DQB1 negative for Aspartic 
      acid at the position 57 (Asp57) (OR = 9.0) alleles appear to be important genetic 
      markers for T1D susceptibility, with higher odds ratio values than any single 
      allele and than most of the haplotypes. Genotypes generated by the association of 
      markers Arg52 DQA1 positive and Asp57 DQB1 negative increase T1D susceptibility 
      much more than one would expected by a simple additive effect of those markers 
      separately (OR = 26.9). This study also confirms an increased risk for 
      DRB1*04/DRB1*03 heterozygote genotypes (OR = 16.8) and also a 
      DRB1*04-DQA1*03:01-DQB1*03:02 haplotype susceptibility dependent on the DRB1*04 
      allele (DRB1*04:01, OR = 7.9; DRB1*04:02, OR = 3.2; DRB1*04:04, OR = 22.1).
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Spinola, H
AU  - Spinola H
AUID- ORCID: 0000-0002-6455-1595
AD  - Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
FAU - Lemos, A
AU  - Lemos A
AD  - Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
FAU - Couto, A R
AU  - Couto AR
AD  - SEEBMO, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal.
AD  - Institute for Molecular and Cell Biology (IBMC), Porto, Portugal.
FAU - Parreira, B
AU  - Parreira B
AD  - SEEBMO, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal.
AD  - Institute for Molecular and Cell Biology (IBMC), Porto, Portugal.
FAU - Soares, M
AU  - Soares M
AD  - SEEBMO, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal.
AD  - Institute for Molecular and Cell Biology (IBMC), Porto, Portugal.
FAU - Dutra, I
AU  - Dutra I
AD  - SEEBMO, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal.
AD  - Institute for Molecular and Cell Biology (IBMC), Porto, Portugal.
FAU - Bruges-Armas, J
AU  - Bruges-Armas J
AD  - SEEBMO, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal.
AD  - Institute for Molecular and Cell Biology (IBMC), Porto, Portugal.
FAU - Brehm, A
AU  - Brehm A
AD  - Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
FAU - Abreu, S
AU  - Abreu S
AD  - Endocrinology Service, Hospital Central do Funchal, Funchal, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20170820
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - *Alleles
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Islands
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Portugal
OTO - NOTNLM
OT  - HLA-DQA1
OT  - HLA-DQB1
OT  - Madeira Island
OT  - Portugal
OT  - type 1 diabetes
EDAT- 2017/08/24 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/01/17 00:00 [received]
PHST- 2017/05/12 00:00 [revised]
PHST- 2017/07/20 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - 10.1111/iji.12335 [doi]
PST - ppublish
SO  - Int J Immunogenet. 2017 Dec;44(6):305-313. doi: 10.1111/iji.12335. Epub 2017 Aug 
      20.