PMID- 28834247
OWN - NLM
STAT- MEDLINE
DCOM- 20190828
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 106
IP  - 4
DP  - 2018 May
TI  - Regeneration of the cementum and periodontal ligament using local BDNF delivery 
      in class II furcation defects.
PG  - 1611-1617
LID - 10.1002/jbm.b.33977 [doi]
AB  - Periodontal furcation defects are usually addressed by the placement of a 
      physical barrier which may limit the regenerative potential of periodontal 
      wounds. This study morphometrically quantified the regenerative effect of 
      brain-derived neurotrophic factor (BDNF) in furcation defects in a non-human 
      primate model. Grade II furcation defects (with and without induced inflammation 
      prior to surgery) were created on the first and second molars of eight non-human 
      primates. Defects were treated with open flap debridement and subsequently filled 
      with either: Group A; BDNF (500 microg mL(-1) ) in high-molecular weight-hyaluronic 
      acid (HMW-HA), Group B; BDNF (50 microg mL(-1) ) in HMW-HA, Group C; HMW-HA acid 
      only, Group D; unfilled defect, or Group E; BDNF (500 microg mL(-1) ) in saline. 
      Periodontal wound healing was observed every 2 weeks by computed-tomography. At 
      11 weeks all animals were sacrificed and maxillary and mandibular block biopsies 
      were referred for nondecalcified histology. Linear measurements of new cementum 
      (cellular and acellular) and periodontal ligament (PDL) formation were performed. 
      Computerized-tomography reconstruction and software quantification demonstrated 
      successful bone fill for all groups. However, histometric assessment demonstrated 
      significantly higher level of total periodontal regeneration for the 500 microg 
      mL(-1) BDNF HMW-HA relative to all other groups. No significant differences in 
      cementogenesis were observed among groups. Significantly higher acellular 
      cementum formation was observed for sites where inflammation was not induced 
      prior to surgical procedures. While all groups experienced similar bone fill and 
      cementogenesis, the 500 microg mL(-1) BDNF HMW-HA appeared to most effectively repair 
      PDL (minimum increase of  approximately 22% relative to all groups; over 200% relative to 
      unfilled defects). (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl 
      Biomater, 106B: 1611-1617, 2018.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Jimbo, Ryo
AU  - Jimbo R
AUID- ORCID: 0000-0003-1945-1074
AD  - Department of Oral and Maxillofacial Surgery, Faculty of Odontology, Malmo 
      University, Sweden.
FAU - Singer, Jessica
AU  - Singer J
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York.
FAU - Tovar, Nick
AU  - Tovar N
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York.
FAU - Marin, Charles
AU  - Marin C
AD  - Postgraduate Program in Dentistry, UNIGRANRIO, Duque de Caxias, Rio de Janeiro, 
      Brazil.
FAU - Neiva, Rodrigo
AU  - Neiva R
AD  - Department of Periodontology, University of Florida, Gainesville, Florida.
FAU - Bonfante, Estevam A
AU  - Bonfante EA
AD  - Department of Prosthodontics and Periodontology, University of Sao Paulo-Bauru 
      School of Dentistry, Bauru, SP, Brazil.
FAU - Janal, Malvin N
AU  - Janal MN
AD  - Department of Public Health and Epidemiology, New York University College of 
      Dentistry, New York, New York.
FAU - Contamin, Hugues
AU  - Contamin H
AD  - Researcher at Cynbiose, 69280 Marcy l'Etoile, Lyon, France.
FAU - Coelho, Paulo G
AU  - Coelho PG
AD  - Department of Biomaterials and Biomimetics, New York University College of 
      Dentistry, New York, New York.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170821
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Dental Cementum/injuries/*physiology
MH  - *Furcation Defects/metabolism/therapy
MH  - Guided Tissue Regeneration, Periodontal/*methods
MH  - Humans
MH  - Hyaluronic Acid/pharmacology
MH  - Macaca fascicularis
MH  - Mandible/metabolism
MH  - Maxilla/metabolism
MH  - Molar/*physiology
MH  - *Periodontal Ligament/injuries/physiology
MH  - Regeneration/*drug effects
OTO - NOTNLM
OT  - BDNF
OT  - furcation
OT  - histomorphometry
OT  - hyaluronic acid
OT  - periodontal regeneration
EDAT- 2017/08/24 06:00
MHDA- 2019/08/29 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/07/13 00:00 [revised]
PHST- 2017/07/29 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2019/08/29 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - 10.1002/jbm.b.33977 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2018 May;106(4):1611-1617. doi: 
      10.1002/jbm.b.33977. Epub 2017 Aug 21.