PMID- 28834666
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2055-5822 (Electronic)
IS  - 2055-5822 (Linking)
VI  - 1
IP  - 1
DP  - 2014 Sep
TI  - Effects of long-term endurance and resistance training on diastolic function, 
      exercise capacity, and quality of life in asymptomatic diastolic dysfunction vs. 
      heart failure with preserved ejection fraction.
PG  - 59-74
LID - 10.1002/ehf2.12007 [doi]
AB  - BACKGROUND: The long-term effects of exercise training (ET) in diastolic 
      dysfunction (DD) and heart failure with preserved ejection fraction (HFpEF) are 
      unknown. The present study compared the long-term effects of ET on exercise 
      capacity, diastolic function, and quality of life (QoL) in patients with DD vs. 
      HFpEF. METHODS: A total of n = 43 patients with asymptomatic DD (n = 19) or HFpEF 
      [DD and New York Heart Association (NYHA) >/=II, n = 24] and left ventricular 
      ejection fraction >/=50% performed a combined endurance/resistance training over 
      6 months (2-3/week) on top of usual care. Cardiopulmonary exercise testing, 
      echocardiography, and QoL were obtained at baseline and follow-up. RESULTS: 
      Patients were 62 +/- 8 years old (37% female). In the HFpEF group, 67% of patients 
      were in NYHA class II (33% in NYHA III). Exercise capacity (peak oxygen 
      consumption, peak VO(2) ) differed at baseline (DD 29.2 +/- 8.7 mL/min/kg vs. HFpEF 
      17.8 +/- 4.6 mL/min/kg; P = 0.004). After 6 months, peak VO(2) increased 
      significantly (P < 0.044) to 19.7 +/- 5.8 mL/min/kg in the HFpEF group and also in 
      the DD group (to 32.8 +/- 8.5 mL/min/kg; P < 0.002) with no overall difference 
      between the groups (P = 0.217). E/e' ratio (left ventricular filling index) 
      decreased from 12.2 +/- 3.5 to 10.1 +/- 3.0 (P < 0.002) in patients with HFpEF and 
      also in patients with DD (10.7 +/- 3.1 vs. 9.5 +/- 2.3; P = 0.03; difference between 
      groups P = 0.210). In contrast, left atrial volume index decreased in the HFpEF 
      group (P < 0.001) but remained stable within the DD group (difference between 
      groups P = 0.015). After 6 months, physical QoL (Minnesota living with heart 
      failure Questionnaire, 36-item short form health survey), general health 
      perception, and 9-item patient health questionnaire score only improved in HFpEF 
      (P < 0.05). In contrast, vitality improved in both groups (difference between 
      groups P = 0.708). CONCLUSION: A structured 6 months ET programme effectively 
      improves exercise capacity and diastolic function in patients with DD and overt 
      HFpEF. Therefore, controlled lifestyle modification with physical activity is 
      effective both in DD and HFpEF.
CI  - (c) 2014 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on 
      behalf of the European Society of Cardiology.
FAU - Nolte, Kathleen
AU  - Nolte K
AD  - Department of Cardiology, University of Gottingen, Robert-Koch-Str. 40, D-37075, 
      Gottingen, Germany.
FAU - Schwarz, Silja
AU  - Schwarz S
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Munich & German 
      Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 
      Technische Universitat Munchen, Georg-Brauchle-Ring 56 (Campus C), D-80992, 
      Munich, Germany.
FAU - Gelbrich, Gotz
AU  - Gelbrich G
AD  - Institute for Epidemiology and Biometry, University of Wurzburg, Sanderring 2, 
      D-97070, Wurzburg, Germany.
FAU - Mensching, Steffen
AU  - Mensching S
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Munich & German 
      Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 
      Technische Universitat Munchen, Georg-Brauchle-Ring 56 (Campus C), D-80992, 
      Munich, Germany.
FAU - Siegmund, Friederike
AU  - Siegmund F
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Munich & German 
      Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 
      Technische Universitat Munchen, Georg-Brauchle-Ring 56 (Campus C), D-80992, 
      Munich, Germany.
FAU - Wachter, Rolf
AU  - Wachter R
AD  - Department of Cardiology, University of Gottingen, Robert-Koch-Str. 40, D-37075, 
      Gottingen, Germany.
AD  - German Center for Cardiovascular Research Site Gottingen, DZHK, Oudenarder Strasse 
      16, Building D/04 (First Floor), 13347, Berlin, Germany.
FAU - Hasenfuss, Gerd
AU  - Hasenfuss G
AD  - Department of Cardiology, University of Gottingen, Robert-Koch-Str. 40, D-37075, 
      Gottingen, Germany.
AD  - German Center for Cardiovascular Research Site Gottingen, DZHK, Oudenarder Strasse 
      16, Building D/04 (First Floor), 13347, Berlin, Germany.
FAU - Dungen, Hans-Dirk
AU  - Dungen HD
AD  - Campus Virchow-Klinikum, Department of Cardiology, Charite-Universitatsmedizin, 
      Augustenburger Platz 1, D-13353, Berlin, Germany.
FAU - Herrmann-Lingen, Christoph
AU  - Herrmann-Lingen C
AD  - German Center for Cardiovascular Research Site Gottingen, DZHK, Oudenarder Strasse 
      16, Building D/04 (First Floor), 13347, Berlin, Germany.
AD  - Department of Psychosomatic Medicine and Psychotherapy, German Centre for 
      Cardiovascular Research, University of Gottingen, Wilhelmsplatz 1, 37073, 
      Gottingen, Germany.
FAU - Halle, Martin
AU  - Halle M
AD  - Department of Prevention, Rehabilitation and Sports Medicine, Munich & German 
      Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 
      Technische Universitat Munchen, Georg-Brauchle-Ring 56 (Campus C), D-80992, 
      Munich, Germany.
FAU - Pieske, Burkert
AU  - Pieske B
AD  - Department of Cardiology, Medical University of Graz, Auenbrugger Platz15, 
      A-8036, Graz, Austria.
FAU - Edelmann, Frank
AU  - Edelmann F
AD  - Department of Cardiology, University of Gottingen, Robert-Koch-Str. 40, D-37075, 
      Gottingen, Germany.
AD  - German Center for Cardiovascular Research Site Gottingen, DZHK, Oudenarder Strasse 
      16, Building D/04 (First Floor), 13347, Berlin, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - ESC Heart Fail
JT  - ESC heart failure
JID - 101669191
OTO - NOTNLM
OT  - Diastolic dysfunction
OT  - Exercise training
OT  - Heart failure with preserved ejection fraction
EDAT- 2014/09/01 00:00
MHDA- 2014/09/01 00:01
CRDT- 2017/08/24 06:00
PHST- 2014/07/14 00:00 [received]
PHST- 2014/08/05 00:00 [revised]
PHST- 2014/08/05 00:00 [accepted]
PHST- 2017/08/24 06:00 [entrez]
PHST- 2014/09/01 00:00 [pubmed]
PHST- 2014/09/01 00:01 [medline]
AID - 10.1002/ehf2.12007 [doi]
PST - ppublish
SO  - ESC Heart Fail. 2014 Sep;1(1):59-74. doi: 10.1002/ehf2.12007.