PMID- 28834779
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20181202
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 43
DP  - 2018 Feb
TI  - Revisiting the prognostic value of monocyte chemotactic protein 1 and 
      interleukin-6 in the sepsis-3 era.
PG  - 21-28
LID - S0883-9441(17)30847-X [pii]
LID - 10.1016/j.jcrc.2017.08.024 [doi]
AB  - BACKGROUND: Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria 
      are poorly represented within studies evaluating biomarkers in sepsis. Therefore, 
      this study evaluates the prognostic value of MCP-1 compared to interleukin-6 
      (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria. 
      METHODS: 136 patients with sepsis or septic shock were included within 24h of 
      intensive care unit (ICU) admission. MCP-1, IL-6, procalcitonin (PCT), C-reactive 
      protein (CRP) and white blood cells (WBC) were measured on days 1, 3 and 8. 
      All-cause mortality was followed up at 30days and 6months. RESULTS: Both MCP-1 
      and IL-6 levels revealed valuable prognostic discrimination of 30-day and 
      6-months all-cause mortality on day 1 and 3 (MCP-1: range of AUCs 0.62-0.65, 
      p<0.039; IL-6: range of AUCs 0.65-0.70, p<0.021) compared to PCT, CRP, SOFA and 
      APACHE II score. MCP-1 levels within the 4th quartile revealed the highest 
      mortality at 30days and 6months compared to patients with lower levels (range of 
      hazard ratio (HR)=2.1-3.3, p<0.041). The prognostic value of MCP-1 sustained in 
      multivariate regression models and was comparable to that of IL-6. CONCLUSION: 
      Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause 
      mortality in patients with sepsis and septic shock according to latest sepsis-3 
      definitions.
CI  - Published by Elsevier Inc.
FAU - Barre, Max
AU  - Barre M
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Behnes, Michael
AU  - Behnes M
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Hamed, Sonja
AU  - Hamed S
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Pauly, Dominic
AU  - Pauly D
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Lepiorz, Dominic
AU  - Lepiorz D
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Lang, Siegfried
AU  - Lang S
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Akin, Ibrahim
AU  - Akin I
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Bertsch, Thomas
AU  - Bertsch T
AD  - Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, 
      General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany.
FAU - Hoffmann, Ursula
AU  - Hoffmann U
AD  - From the First Department of Medicine (M.Ba., M.Be., S.H., D.P., D.L., S.L., 
      I.A., M.Bo., U.H.), University Medical Centre Mannheim (UMM), Faculty of Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: 
      Ursula.Hoffmann@umm.de.
LA  - eng
PT  - Journal Article
DEP - 20170815
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Calcitonin/*blood
MH  - Chemokine CCL2/*blood
MH  - *Critical Care
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intensive Care Units
MH  - Interleukin-6/*blood
MH  - Leukocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Sepsis/*blood/mortality/therapy
OTO - NOTNLM
OT  - Biomarker
OT  - Intensive care unit
OT  - MCP-1
OT  - Prognosis
OT  - Sepsis
OT  - Septic shock
EDAT- 2017/08/24 06:00
MHDA- 2018/09/18 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/06/07 00:00 [received]
PHST- 2017/08/06 00:00 [revised]
PHST- 2017/08/12 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - S0883-9441(17)30847-X [pii]
AID - 10.1016/j.jcrc.2017.08.024 [doi]
PST - ppublish
SO  - J Crit Care. 2018 Feb;43:21-28. doi: 10.1016/j.jcrc.2017.08.024. Epub 2017 Aug 
      15.