PMID- 28835859
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2017
DP  - 2017
TI  - Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with 
      Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma.
PG  - 8496978
LID - 10.1155/2017/8496978 [doi]
LID - 8496978
AB  - Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive 
      clinicopathologic features has been recognized; it is characterized by 
      involvement of bone marrow with or without liver and/or spleen, but no lymph node 
      or other extranodal sites, usually associated with fever, anemia, and 
      hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical 
      presentation, it has been designated "bone marrow-liver-spleen" (BLS) type of 
      LBCL. To date there is only one series of 11 cases of BLS type of LBCL with 
      detailed clinical, pathologic, and cytogenetic data. Herein, we describe a case 
      of BLS type LBCL presenting with associated HLH in a 73-year-old female. The bone 
      marrow core biopsy showed cytologically atypical large lymphoma cells present in 
      a scattered interstitial distribution and hemophagocytosis and infrequent large 
      lymphoma cells were seen in the bone marrow aspirate smears. Circulating lymphoma 
      cells were not seen in the peripheral blood smears. The patient underwent 
      treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after 
      initial presentation. BLS type of LBCL is a very rare and clinically aggressive 
      lymphoma whose identification may be delayed by clinicians and hematopathologists 
      due to its unusual clinical presentation and pathologic features.
FAU - Lyapichev, Kirill A
AU  - Lyapichev KA
AUID- ORCID: 0000-0001-9983-9735
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
FAU - Chapman, Jennifer R
AU  - Chapman JR
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
FAU - Iakymenko, Oleksii
AU  - Iakymenko O
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
FAU - Ikpatt, Offiong F
AU  - Ikpatt OF
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
FAU - Teomete, Uygar
AU  - Teomete U
AD  - Department of Radiology, University of Miami and Sylvester Comprehensive Cancer 
      Center, Miami, FL, USA.
FAU - Sanchez, Sandra Patricia
AU  - Sanchez SP
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
FAU - Vega, Francisco
AU  - Vega F
AUID- ORCID: 0000-0001-5956-452X
AD  - Division of Hematopathology, Department of Pathology and Laboratory Medicine, 
      University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
AD  - Division of Hematology-Oncology, Department of Medicine, University of Miami and 
      Sylvester Comprehensive Cancer Center, Miami, FL, USA.
LA  - eng
PT  - Case Reports
DEP - 20170801
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC5556984
EDAT- 2017/08/25 06:00
MHDA- 2017/08/25 06:01
PMCR- 2017/08/01
CRDT- 2017/08/25 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/08/25 06:00 [entrez]
PHST- 2017/08/25 06:00 [pubmed]
PHST- 2017/08/25 06:01 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 10.1155/2017/8496978 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2017;2017:8496978. doi: 10.1155/2017/8496978. Epub 2017 Aug 1.