PMID- 28836013
OWN - NLM
STAT- MEDLINE
DCOM- 20180330
LR  - 20181202
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Jan
TI  - Enhanced survival of ischemic skin flap by combined treatment with bone 
      marrow-derived stem cells and low-level light irradiation.
PG  - 1-9
LID - 10.1007/s10103-017-2312-9 [doi]
AB  - The aim of this study is to examine the enhanced survival effect of ischemic skin 
      flap by combined treatment with bone marrow-derived stem cells (BMSCs) and 
      low-level light irradiation (LLLI). The neovasculogenic effect of BMSCs induced 
      by LLLI was detected using a wound healing and tube formation assay. ICR mice 
      were divided into four groups: control group, LLLI group, BMSCs group, and 
      combine-treated group. The percentage of skin flap necrosis area was calculated 
      on the seventh post-operative day. Specimens were harvested for histologic 
      analyses. LLLI promoted BMSC migration and tube formation. The flap survival rate 
      of combined treated group was significantly higher than that of the control 
      group. Histologic results demonstrated a significant increase in 
      neovascularization in the combined treatment group. This study demonstrates that 
      combination treatment of BMSCs and LLLI could enhance the survival of ischemic 
      skin flap in a mouse model.
FAU - Moon, Jeong Hwan
AU  - Moon JH
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook 
      University, 119 Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea.
AD  - Laser Translational Clinical Trial Center Beckman Laser Institute Korea, Dankook 
      University, 119 Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea.
FAU - Rhee, Yun-Hee
AU  - Rhee YH
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea.
FAU - Ahn, Jin-Chul
AU  - Ahn JC
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea.
AD  - Department of Biomedical Science, College of Medicine, Dankook University, 119 
      Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea.
FAU - Kim, Bongkyun
AU  - Kim B
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea.
FAU - Lee, Sang Joon
AU  - Lee SJ
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook 
      University, 119 Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea.
FAU - Chung, Phil-Sang
AU  - Chung PS
AD  - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Dankook 
      University, 119 Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea. 
      12030445@dankook.ac.kr.
AD  - Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 
      Chungnam, 330-714, Republic of Korea. 12030445@dankook.ac.kr.
AD  - Laser Translational Clinical Trial Center Beckman Laser Institute Korea, Dankook 
      University, 119 Dandae-ro, Cheonan, Chungnam, 330-714, Republic of Korea. 
      12030445@dankook.ac.kr.
LA  - eng
GR  - HI14C1234/the Ministry of Health & Welfare, Republic of Korea/
PT  - Journal Article
DEP - 20170823
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Immunohistochemistry
MH  - Ischemia/*radiotherapy
MH  - *Low-Level Light Therapy
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology/radiation effects
MH  - Mice, Inbred ICR
MH  - Necrosis
MH  - Neovascularization, Physiologic/radiation effects
MH  - Perfusion
MH  - Reproducibility of Results
MH  - Surgical Flaps/*blood supply
MH  - Wound Healing
OTO - NOTNLM
OT  - Bone marrow-derived stem cell
OT  - Ischemia
OT  - Low-level light
OT  - Neovascularization
OT  - Skin flap
EDAT- 2017/08/25 06:00
MHDA- 2018/03/31 06:00
CRDT- 2017/08/25 06:00
PHST- 2017/05/31 00:00 [received]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2017/08/25 06:00 [pubmed]
PHST- 2018/03/31 06:00 [medline]
PHST- 2017/08/25 06:00 [entrez]
AID - 10.1007/s10103-017-2312-9 [pii]
AID - 10.1007/s10103-017-2312-9 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2018 Jan;33(1):1-9. doi: 10.1007/s10103-017-2312-9. Epub 2017 Aug 
      23.