PMID- 28836830
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180122
LR  - 20180124
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 25
IP  - 7
DP  - 2016 Jul
TI  - Functional Recovery after the Transplantation of Neurally Differentiated 
      Mesenchymal Stem Cells Derived from Bone Marrow in a Rat Model of Spinal Cord 
      Injury.
PG  - 1423
LID - 10.3727/096368916X692078 [doi]
AB  - This study was designed to investigate functional recovery after the 
      transplantation of mesenchymal stem cells (MSCs) or neurally differentiated MSCs 
      (NMSCs) derived from bone marrow in a rat model of spinal cord injury (SCI). 
      Sprague-Dawley rats were subjected to incomplete SCI using an NYU impactor to 
      create a free drop contusion at the T9 level. The SCI rats were then classified 
      into three groups; MSCs, NMSCs, and phosphate-buffered saline (PBS)-treated 
      groups. The cells or PBS were administrated 1 week after SCI. 
      Basso-Beattie-Bresnahan (BBB) locomotor rating scores were measured at 1-week 
      intervals for 9 weeks. Somatosensory evoked potentials (SSEPs) and motor evoked 
      potentials (MEPs) were also recorded 8 weeks after transplantation. While 
      transplantation of MSCs led to a clear tendency of motor recovery, NMSC-treated 
      rats had significantly improved BBB scores and showed significantly shortened 
      initial latency, N1 latency, and P1 latency of the SSEPs compared to PBS 
      controls. In addition, 5-bromo-2-deoxyuridine (BrdU)-prelabeled MSCs costained 
      for BrdU and glial fibrillary acidic protein (GFAP) or myelin basic protein (MBP) 
      were found rostrally and caudally 5 mm each from the epicenter of the necrotic 
      cavity 4 weeks after transplantation. These results suggest that neurally 
      differentiated cells might be an effective therapeutic source for functional 
      recovery after SCI.
FAU - Cho, Sung-Rae
AU  - Cho SR
AD  - Department & Research Institute of Rehabilitation Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Kim, Yong Rae
AU  - Kim YR
AD  - Department of Rehabilitation Medicine, Pochun Joongmoon University College of 
      Medicine, Seoul, Korea.
FAU - Kang, Hoi-Sung
AU  - Kang HS
AD  - Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, 
      Korea.
FAU - Yim, Sun Hee
AU  - Yim SH
AD  - Department & Research Institute of Rehabilitation Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Chang-Il
AU  - Park CI
AD  - Department & Research Institute of Rehabilitation Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Min, Yoo Hong
AU  - Min YH
AD  - Department of Hematology, Yonsei University College of Medicine, Seoul, Korea.
FAU - Lee, Bae Hwan
AU  - Lee BH
AD  - Department of Physiology, Brain Research Institute and Brain Korea 21 Project for 
      Medical Science, Yonsei University College of Medicine, Seoul, Korea.
FAU - Shin, Ji Cheol
AU  - Shin JC
AD  - Department & Research Institute of Rehabilitation Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Lim, Jong-Baeck
AU  - Lim JB
AD  - Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Published Erratum
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
EFR - Cell Transplant. 2009;18(12):1359-68. PMID: 20184788
OTO - NOTNLM
OT  - Functional recovery
OT  - Mesenchymal stem cells (MSCs)
OT  - Neural differentiation
OT  - Spinal cord injury
OT  - Transplantation
EDAT- 2017/08/25 06:00
MHDA- 2017/08/25 06:01
CRDT- 2017/08/25 06:00
PHST- 2017/08/25 06:00 [entrez]
PHST- 2017/08/25 06:00 [pubmed]
PHST- 2017/08/25 06:01 [medline]
AID - 10.3727/096368916X692078 [doi]
PST - ppublish
SO  - Cell Transplant. 2016 Jul;25(7):1423. doi: 10.3727/096368916X692078.