PMID- 28836886
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 286
IP  - 1
DP  - 2018 Jan
TI  - Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture 
      Analysis on Nonenhanced Cine MR Images.
PG  - 103-112
LID - 10.1148/radiol.2017170213 [doi]
AB  - Purpose To test whether texture analysis (TA) allows for the diagnosis of 
      subacute and chronic myocardial infarction (MI) on noncontrast material-enhanced 
      cine cardiac magnetic resonance (MR) images. Materials and Methods In this 
      retrospective, institutional review board-approved study, 120 patients who 
      underwent cardiac MR imaging and showed large transmural (volume of enhancement 
      on late gadolinium enhancement [LGE] images >20%, n = 72) or small (enhanced 
      volume </=20%, n = 48) subacute or chronic ischemic scars were included. Sixty 
      patients with normal cardiac MR imaging findings served as control subjects. 
      Regions of interest for TA encompassing the left ventricle were drawn by two 
      blinded, independent readers on cine images in end systole by using a freely 
      available software package. Stepwise dimension reduction and texture feature 
      selection based on reproducibility, machine learning, and correlation analyses 
      were performed for selecting features, enabling the diagnosis of MI on 
      nonenhanced cine MR images by using LGE imaging as the standard of reference. 
      Results Five independent texture features allowed for differentiation between 
      ischemic scar and normal myocardium on cine MR images in both subgroups: Teta1, 
      Perc.01, Variance, WavEnHH.s-3, and S(5,5)SumEntrp (in patients with large MI: 
      all P values < .001; in patients with small MI: Teta1 and Perc.01, P < .001; 
      Variance, P = .026; WavEnHH.s-3, P = .007; S[5,5]SumEntrp, P = .045). Multiple 
      logistic regression models revealed that combining the features Teta1 and Perc.01 
      resulted in the highest accuracy for diagnosing large and small MI on cine MR 
      images, with an area under the curve of 0.93 and 0.92, respectively. Conclusion 
      This proof-of-concept study indicates that TA of nonenhanced cine MR images 
      allows for the diagnosis of subacute and chronic MI with high accuracy. ((c)) RSNA, 
      2017 Online supplemental material is available for this article.
FAU - Baessler, Bettina
AU  - Baessler B
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
FAU - Mannil, Manoj
AU  - Mannil M
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
FAU - Oebel, Sabrina
AU  - Oebel S
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
FAU - Maintz, David
AU  - Maintz D
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
FAU - Alkadhi, Hatem
AU  - Alkadhi H
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
FAU - Manka, Robert
AU  - Manka R
AD  - From the Institute of Diagnostic and Interventional Radiology, University 
      Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091 Zurich, 
      Switzerland (B.B., M.M., S.O., H.A., R.M.); Department of Radiology, University 
      Hospital of Cologne, Cologne, Germany (B.B., D.M.); Department of Cardiology, 
      University Heart Center Zurich, Zurich, Switzerland (S.O., R.M.); and Institute 
      for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland 
      (R.M.).
LA  - eng
PT  - Journal Article
DEP - 20170823
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Cicatrix/diagnostic imaging
MH  - Female
MH  - Heart/diagnostic imaging
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Myocardium/*pathology
MH  - Retrospective Studies
EDAT- 2017/08/25 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/08/25 06:00
PHST- 2017/08/25 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/08/25 06:00 [entrez]
AID - 10.1148/radiol.2017170213 [doi]
PST - ppublish
SO  - Radiology. 2018 Jan;286(1):103-112. doi: 10.1148/radiol.2017170213. Epub 2017 Aug 
      23.