PMID- 28837087
OWN - NLM
STAT- MEDLINE
DCOM- 20180608
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Aug 24
TI  - Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing 
      Brain BDNF Levels.
LID - 10.3390/nu9090931 [doi]
LID - 931
AB  - The decrease of brain-derived neurotrophic factor (BDNF) has been reported in 
      alcohol use disorder and major depression. The effective treatment of these 
      comorbid diseases remains undiscovered. Nutraceutical products are therefore 
      proposed as an alternative approach to overcome this challenge. Ginseng extract 
      G115, the standardized extract of Panax ginseng, is a widely-used nutraceutical 
      that is beneficial for various central nervous system disorders. This study aimed 
      to determine the antidepressant effect of ginseng extract G115 in ethanol-treated 
      mice models. Mice received either water, amitriptyline, or various doses of G115 
      (p.o.) followed by water or ethanol (i.p.) for 8 days. The antidepressant 
      activity was evaluated using forced swimming test. BDNF levels were measured from 
      hippocampal and prefrontal cortex tissues. The results demonstrated that the 
      increase of immobility time in depressant mice induced by ethanol was reversed by 
      both G115 and amitriptyline treatment. A significant increase of BDNF levels in 
      the hippocampus and prefrontal cortex was observed in ethanol-treated mice 
      receiving G115. Taken together, this study provides scientific information on the 
      use of G115 as an antidepressant that could be further used as a dietary 
      supplement in comorbid alcohol use and major depressive disorders.
FAU - Boonlert, Weerawan
AU  - Boonlert W
AD  - Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, 
      Chulalongkorn University, Bangkok 10330, Thailand. one_tsuke@hotmail.com.
FAU - Benya-Aphikul, Hattaya
AU  - Benya-Aphikul H
AD  - Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, 
      Chulalongkorn University, Bangkok 10330, Thailand. h.benyaaphikul@gmail.com.
FAU - Umka Welbat, Jariya
AU  - Umka Welbat J
AD  - Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 
      40002, Thailand. jariya@kku.ac.th.
FAU - Rodsiri, Ratchanee
AU  - Rodsiri R
AD  - Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, 
      Chulalongkorn University, Bangkok 10330, Thailand. ratchanee.r@pharm.chula.ac.th.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170824
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 1806D8D52K (Amitriptyline)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Amitriptyline/pharmacology
MH  - Animals
MH  - Antidepressive Agents/isolation & purification/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/chemically induced/metabolism/*prevention & control/psychology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - *Ethanol
MH  - Hippocampus/*drug effects/metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Mice, Inbred ICR
MH  - *Panax/chemistry
MH  - Phytotherapy
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Plants, Medicinal
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Swimming
MH  - Up-Regulation
PMC - PMC5622691
OTO - NOTNLM
OT  - BDNF
OT  - Panax ginseng
OT  - depression
OT  - ethanol
OT  - ginseng extract G115
OT  - mice
COIS- The authors declare no conflict of interest.
EDAT- 2017/08/25 06:00
MHDA- 2018/06/09 06:00
PMCR- 2017/09/01
CRDT- 2017/08/25 06:00
PHST- 2017/07/16 00:00 [received]
PHST- 2017/08/17 00:00 [revised]
PHST- 2017/08/20 00:00 [accepted]
PHST- 2017/08/25 06:00 [entrez]
PHST- 2017/08/25 06:00 [pubmed]
PHST- 2018/06/09 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - nu9090931 [pii]
AID - nutrients-09-00931 [pii]
AID - 10.3390/nu9090931 [doi]
PST - epublish
SO  - Nutrients. 2017 Aug 24;9(9):931. doi: 10.3390/nu9090931.